Nonvirally Modified Autologous Primary Hepatocytes Correct Diabetes and Prevent Target Organ Injury in a Large Preclinical Model

BACKGROUND: Current gene- and cell-based therapies have significant limitations which impede widespread clinical application. Taking diabetes mellitus as a paradigm, we have sought to overcome these limitations by ex vivo electrotransfer of a nonviral insulin expression vector into primary hepatocyt...

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Detalles Bibliográficos
Autores principales: Chen, Nelson K. F., Wong, Jen San, Kee, Irene H. C., Lai, Siang Hui, Thng, Choon Hua, Ng, Wai Har, Ng, Robert T. H., Tan, Soo Yong, Lee, Shu Yen, Tan, Mark E. H., Sivalingam, Jaichandran, Chow, Pierce K. H., Kon, Oi Lian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249706/
https://www.ncbi.nlm.nih.gov/pubmed/18320053
http://dx.doi.org/10.1371/journal.pone.0001734

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