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Parkin occurs in a stable, non-covalent, ∼110-kDa complex in brain
Mutations in the gene for parkin, a 52-kDa E3 ubiquitin ligase, are a major cause of hereditary Parkinson's disease (PD). In vitro studies have identified a large number of parkin-interacting proteins. Whether parkin exists as a monomer or as part of a stable protein complex in vivo is uncertai...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253705/ https://www.ncbi.nlm.nih.gov/pubmed/18190519 http://dx.doi.org/10.1111/j.1460-9568.2007.06000.x |