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Estimating effects of rare haplotypes on failure time using a penalized Cox proportional hazards regression model
BACKGROUND: This paper describes a likelihood approach to model the relation between failure time and haplotypes in studies with unrelated individuals where haplotype phase is unknown, while dealing with the problem of unstable estimates due to rare haplotypes by considering a penalized log-likeliho...
Autores principales: | Souverein, Olga W, Zwinderman, Aeilko H, Jukema, J Wouter, Tanck, Michael WT |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254440/ https://www.ncbi.nlm.nih.gov/pubmed/18221501 http://dx.doi.org/10.1186/1471-2156-9-9 |
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