Control of Muscle Mitochondria by Insulin Entails Activation of Akt2-mtNOS Pathway: Implications for the Metabolic Syndrome

BACKGROUND: In the metabolic syndrome with hyperinsulinemia, mitochondrial inhibition facilitates muscle fat and glycogen accumulation and accelerates its progression. In the last decade, nitric oxide (NO) emerged as a typical mitochondrial modulator by reversibly inhibiting citochrome oxidase and o...

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Detalles Bibliográficos
Autores principales: Finocchietto, Paola, Barreyro, Fernando, Holod, Silvia, Peralta, Jorge, Franco, María C., Méndez, Carlos, Converso, Daniela P., Estévez, Alvaro, Carreras, Maria C., Poderoso, Juan J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258147/
https://www.ncbi.nlm.nih.gov/pubmed/18335029
http://dx.doi.org/10.1371/journal.pone.0001749

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