SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utili...

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Detalles Bibliográficos
Autores principales: Boily, Gino, Seifert, Erin L., Bevilacqua, Lisa, He, Xiao Hong, Sabourin, Guillaume, Estey, Carmen, Moffat, Cynthia, Crawford, Sean, Saliba, Sarah, Jardine, Karen, Xuan, Jian, Evans, Meredith, Harper, Mary-Ellen, McBurney, Michael W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258149/
https://www.ncbi.nlm.nih.gov/pubmed/18335035
http://dx.doi.org/10.1371/journal.pone.0001759

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