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Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We i...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258178/ https://www.ncbi.nlm.nih.gov/pubmed/18045462 http://dx.doi.org/10.1186/gb-2007-8-11-r253 |
| _version_ | 1782151323055030272 |
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| author | Bergholdt, Regine Størling, Zenia M Lage, Kasper Karlberg, E Olof Ólason, Páll Í Aalund, Mogens Nerup, Jørn Brunak, Søren Workman, Christopher T Pociot, Flemming |
| author_facet | Bergholdt, Regine Størling, Zenia M Lage, Kasper Karlberg, E Olof Ólason, Páll Í Aalund, Mogens Nerup, Jørn Brunak, Søren Workman, Christopher T Pociot, Flemming |
| author_sort | Bergholdt, Regine |
| collection | PubMed |
| description | We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases. |
| format | Text |
| id | pubmed-2258178 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2007 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-22581782008-02-28 Integrative analysis for finding genes and networks involved in diabetes and other complex diseases Bergholdt, Regine Størling, Zenia M Lage, Kasper Karlberg, E Olof Ólason, Páll Í Aalund, Mogens Nerup, Jørn Brunak, Søren Workman, Christopher T Pociot, Flemming Genome Biol Research We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases. BioMed Central 2007 2007-11-28 /pmc/articles/PMC2258178/ /pubmed/18045462 http://dx.doi.org/10.1186/gb-2007-8-11-r253 Text en Copyright © 2007 Bergholdt et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Bergholdt, Regine Størling, Zenia M Lage, Kasper Karlberg, E Olof Ólason, Páll Í Aalund, Mogens Nerup, Jørn Brunak, Søren Workman, Christopher T Pociot, Flemming Integrative analysis for finding genes and networks involved in diabetes and other complex diseases |
| title | Integrative analysis for finding genes and networks involved in diabetes and other complex diseases |
| title_full | Integrative analysis for finding genes and networks involved in diabetes and other complex diseases |
| title_fullStr | Integrative analysis for finding genes and networks involved in diabetes and other complex diseases |
| title_full_unstemmed | Integrative analysis for finding genes and networks involved in diabetes and other complex diseases |
| title_short | Integrative analysis for finding genes and networks involved in diabetes and other complex diseases |
| title_sort | integrative analysis for finding genes and networks involved in diabetes and other complex diseases |
| topic | Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258178/ https://www.ncbi.nlm.nih.gov/pubmed/18045462 http://dx.doi.org/10.1186/gb-2007-8-11-r253 |
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