Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study

A simple, fast, and biologically inspired computational approach for inferring genome-scale rearrangement phylogeny and ancestral gene order has been developed. This has been applied to eight Drosophila genomes. Existing techniques are either limited to a few hundred markers or a small number of tax...

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Detalles Bibliográficos
Autores principales: Bhutkar, Arjun, Gelbart, William M, Smith, Temple F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258185/
https://www.ncbi.nlm.nih.gov/pubmed/17996033
http://dx.doi.org/10.1186/gb-2007-8-11-r236
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author Bhutkar, Arjun
Gelbart, William M
Smith, Temple F
author_facet Bhutkar, Arjun
Gelbart, William M
Smith, Temple F
author_sort Bhutkar, Arjun
collection PubMed
description A simple, fast, and biologically inspired computational approach for inferring genome-scale rearrangement phylogeny and ancestral gene order has been developed. This has been applied to eight Drosophila genomes. Existing techniques are either limited to a few hundred markers or a small number of taxa. This analysis uses over 14,000 genomic loci and employs discrete elements consisting of pairs of homologous genetic elements. The results provide insight into evolutionary chromosomal dynamics and synteny analysis, and inform speciation studies.
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spelling pubmed-22581852008-02-28 Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study Bhutkar, Arjun Gelbart, William M Smith, Temple F Genome Biol Method A simple, fast, and biologically inspired computational approach for inferring genome-scale rearrangement phylogeny and ancestral gene order has been developed. This has been applied to eight Drosophila genomes. Existing techniques are either limited to a few hundred markers or a small number of taxa. This analysis uses over 14,000 genomic loci and employs discrete elements consisting of pairs of homologous genetic elements. The results provide insight into evolutionary chromosomal dynamics and synteny analysis, and inform speciation studies. BioMed Central 2007 2007-11-08 /pmc/articles/PMC2258185/ /pubmed/17996033 http://dx.doi.org/10.1186/gb-2007-8-11-r236 Text en Copyright © 2007 Bhutkar et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Bhutkar, Arjun
Gelbart, William M
Smith, Temple F
Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study
title Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study
title_full Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study
title_fullStr Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study
title_full_unstemmed Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study
title_short Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study
title_sort inferring genome-scale rearrangement phylogeny and ancestral gene order: a drosophila case study
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258185/
https://www.ncbi.nlm.nih.gov/pubmed/17996033
http://dx.doi.org/10.1186/gb-2007-8-11-r236
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AT smithtemplef inferringgenomescalerearrangementphylogenyandancestralgeneorderadrosophilacasestudy

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