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Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis
BACKGROUND: Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography and benefit of pharmacological treatment is unclear. Although prophylactic use of corticosteroid for reduction of pancreatic injury after ERCP has been evaluated, discrepancy about beneficial ef...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258301/ https://www.ncbi.nlm.nih.gov/pubmed/18271973 http://dx.doi.org/10.1186/1471-230X-8-6 |
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author | Zheng, Minghua Bai, Jianling Yuan, Bosi Lin, Feng You, Jie Lu, Mingqin Gong, Yuewen Chen, Yongping |
author_facet | Zheng, Minghua Bai, Jianling Yuan, Bosi Lin, Feng You, Jie Lu, Mingqin Gong, Yuewen Chen, Yongping |
author_sort | Zheng, Minghua |
collection | PubMed |
description | BACKGROUND: Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography and benefit of pharmacological treatment is unclear. Although prophylactic use of corticosteroid for reduction of pancreatic injury after ERCP has been evaluated, discrepancy about beneficial effect of corticosteroid on pancreatic injury still exists. The aim of current study is to evaluate effectiveness and safety of corticosteroid in prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). METHODS: We employed the method recommended by the Cochrane Collaboration to perform a meta-analysis of seven randomized controlled trials (RCTs) of corticosteroid in prevention of post-ERCP pancreatitis (PEP) around the world. RESULTS: Most of the seven RCTs were of high quality. When the RCTs were analyzed, odds ratios (OR) for corticosteroid were 1.13 [95% CI (0.89~1.44), p = 0.32] for PEP, 1.61 [95% CI (0.74~3.52), p = 0.23] for severe PEP, 0.92 [95% CI (0.57~1.48), p = 0.73] for post-ERCP hyperamylasemia respectively. The results indicated that there were no beneficial effects of corticosteroid on acute pancreatitis and hyperamylasemia. No evidence of publication bias was found. CONCLUSION: Corticosteroids cannot prevent pancreatic injury after ERCP. Therefore, their use in the prophylaxis of PEP is not recommended. |
format | Text |
id | pubmed-2258301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22583012008-02-29 Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis Zheng, Minghua Bai, Jianling Yuan, Bosi Lin, Feng You, Jie Lu, Mingqin Gong, Yuewen Chen, Yongping BMC Gastroenterol Research Article BACKGROUND: Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography and benefit of pharmacological treatment is unclear. Although prophylactic use of corticosteroid for reduction of pancreatic injury after ERCP has been evaluated, discrepancy about beneficial effect of corticosteroid on pancreatic injury still exists. The aim of current study is to evaluate effectiveness and safety of corticosteroid in prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). METHODS: We employed the method recommended by the Cochrane Collaboration to perform a meta-analysis of seven randomized controlled trials (RCTs) of corticosteroid in prevention of post-ERCP pancreatitis (PEP) around the world. RESULTS: Most of the seven RCTs were of high quality. When the RCTs were analyzed, odds ratios (OR) for corticosteroid were 1.13 [95% CI (0.89~1.44), p = 0.32] for PEP, 1.61 [95% CI (0.74~3.52), p = 0.23] for severe PEP, 0.92 [95% CI (0.57~1.48), p = 0.73] for post-ERCP hyperamylasemia respectively. The results indicated that there were no beneficial effects of corticosteroid on acute pancreatitis and hyperamylasemia. No evidence of publication bias was found. CONCLUSION: Corticosteroids cannot prevent pancreatic injury after ERCP. Therefore, their use in the prophylaxis of PEP is not recommended. BioMed Central 2008-02-14 /pmc/articles/PMC2258301/ /pubmed/18271973 http://dx.doi.org/10.1186/1471-230X-8-6 Text en Copyright © 2008 Zheng et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zheng, Minghua Bai, Jianling Yuan, Bosi Lin, Feng You, Jie Lu, Mingqin Gong, Yuewen Chen, Yongping Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis |
title | Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis |
title_full | Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis |
title_fullStr | Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis |
title_full_unstemmed | Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis |
title_short | Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis |
title_sort | meta-analysis of prophylactic corticosteroid use in post-ercp pancreatitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258301/ https://www.ncbi.nlm.nih.gov/pubmed/18271973 http://dx.doi.org/10.1186/1471-230X-8-6 |
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