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SUMO: a ubiquitin-like protein modifier.
SUMO (Small Ubiquitin-related Modifier) is a small protein that covalently attaches to a lysine residue of another protein in a reversible fashion. SUMO attachment to its substrate proteins causes changes in the localization, activity, or binding partners of the substrate. SUMO has been shown to pla...
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Formato: | Texto |
Lenguaje: | English |
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Yale Journal of Biology and Medicine
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259148/ https://www.ncbi.nlm.nih.gov/pubmed/16720014 |
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author | Kroetz, Mary B. |
author_facet | Kroetz, Mary B. |
author_sort | Kroetz, Mary B. |
collection | PubMed |
description | SUMO (Small Ubiquitin-related Modifier) is a small protein that covalently attaches to a lysine residue of another protein in a reversible fashion. SUMO attachment to its substrate proteins causes changes in the localization, activity, or binding partners of the substrate. SUMO has been shown to play a role in a multitude of processes; these include chromosome segregation, cell cycle progression, and DNA damage recovery. Defects in the SUMO pathway have been demonstrated to affect tumorigenesis and the inflammatory response as well as other human diseases. |
format | Text |
id | pubmed-2259148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Yale Journal of Biology and Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-22591482008-03-03 SUMO: a ubiquitin-like protein modifier. Kroetz, Mary B. Yale J Biol Med Research Article SUMO (Small Ubiquitin-related Modifier) is a small protein that covalently attaches to a lysine residue of another protein in a reversible fashion. SUMO attachment to its substrate proteins causes changes in the localization, activity, or binding partners of the substrate. SUMO has been shown to play a role in a multitude of processes; these include chromosome segregation, cell cycle progression, and DNA damage recovery. Defects in the SUMO pathway have been demonstrated to affect tumorigenesis and the inflammatory response as well as other human diseases. Yale Journal of Biology and Medicine 2005-07 /pmc/articles/PMC2259148/ /pubmed/16720014 Text en |
spellingShingle | Research Article Kroetz, Mary B. SUMO: a ubiquitin-like protein modifier. |
title | SUMO: a ubiquitin-like protein modifier. |
title_full | SUMO: a ubiquitin-like protein modifier. |
title_fullStr | SUMO: a ubiquitin-like protein modifier. |
title_full_unstemmed | SUMO: a ubiquitin-like protein modifier. |
title_short | SUMO: a ubiquitin-like protein modifier. |
title_sort | sumo: a ubiquitin-like protein modifier. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259148/ https://www.ncbi.nlm.nih.gov/pubmed/16720014 |
work_keys_str_mv | AT kroetzmaryb sumoaubiquitinlikeproteinmodifier |