The molecular mechanisms of classic Hodgkin's lymphoma.

Classic Hodgkin's lymphoma is characterized by the appearance of giant abnormal cells called Hodgkin and Reed-Sternberg (HRS) cells. HRS cells arise from germinal center B lymphocytes and in about 50 percent of patients, are infected with Epstein-Barr Virus. In addition, HRS cells show constitu...

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Detalles Bibliográficos
Autor principal: Felberbaum, Rachael S.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259149/
https://www.ncbi.nlm.nih.gov/pubmed/16720015
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author Felberbaum, Rachael S.
author_facet Felberbaum, Rachael S.
author_sort Felberbaum, Rachael S.
collection PubMed
description Classic Hodgkin's lymphoma is characterized by the appearance of giant abnormal cells called Hodgkin and Reed-Sternberg (HRS) cells. HRS cells arise from germinal center B lymphocytes and in about 50 percent of patients, are infected with Epstein-Barr Virus. In addition, HRS cells show constitutive NF-kappaB activation and are resistant to apoptosis. This paper reviews several recent studies that for the first time implicate specific molecules in the pathogenesis of classic Hodgkin's lymphoma. Targeting these molecules could lead to the development of novel therapies for this disease.
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spelling pubmed-22591492008-03-03 The molecular mechanisms of classic Hodgkin's lymphoma. Felberbaum, Rachael S. Yale J Biol Med Research Article Classic Hodgkin's lymphoma is characterized by the appearance of giant abnormal cells called Hodgkin and Reed-Sternberg (HRS) cells. HRS cells arise from germinal center B lymphocytes and in about 50 percent of patients, are infected with Epstein-Barr Virus. In addition, HRS cells show constitutive NF-kappaB activation and are resistant to apoptosis. This paper reviews several recent studies that for the first time implicate specific molecules in the pathogenesis of classic Hodgkin's lymphoma. Targeting these molecules could lead to the development of novel therapies for this disease. Yale Journal of Biology and Medicine 2005-07 /pmc/articles/PMC2259149/ /pubmed/16720015 Text en
spellingShingle Research Article
Felberbaum, Rachael S.
The molecular mechanisms of classic Hodgkin's lymphoma.
title The molecular mechanisms of classic Hodgkin's lymphoma.
title_full The molecular mechanisms of classic Hodgkin's lymphoma.
title_fullStr The molecular mechanisms of classic Hodgkin's lymphoma.
title_full_unstemmed The molecular mechanisms of classic Hodgkin's lymphoma.
title_short The molecular mechanisms of classic Hodgkin's lymphoma.
title_sort molecular mechanisms of classic hodgkin's lymphoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259149/
https://www.ncbi.nlm.nih.gov/pubmed/16720015
work_keys_str_mv AT felberbaumrachaels themolecularmechanismsofclassichodgkinslymphoma
AT felberbaumrachaels molecularmechanismsofclassichodgkinslymphoma

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