Clinical implications of mutational analysis in gastrointestinal stromal tumours

The management of localised and advanced gastrointestinal stromal tumours (GISTs) in terms of histological diagnosis, surgery, imaging, medical treatment and molecular biology has rapidly changed since introduction of imatinib mesylate for molecularly targeted therapy in 2000. In this minireview, we...

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Autores principales: Hoeben, A, Schöffski, P, Debiec-Rychter, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259190/
https://www.ncbi.nlm.nih.gov/pubmed/18253129
http://dx.doi.org/10.1038/sj.bjc.6604217
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author Hoeben, A
Schöffski, P
Debiec-Rychter, M
author_facet Hoeben, A
Schöffski, P
Debiec-Rychter, M
author_sort Hoeben, A
collection PubMed
description The management of localised and advanced gastrointestinal stromal tumours (GISTs) in terms of histological diagnosis, surgery, imaging, medical treatment and molecular biology has rapidly changed since introduction of imatinib mesylate for molecularly targeted therapy in 2000. In this minireview, we briefly summarise and discuss the current data relevant to the increasing role of molecular characterisation of GISTs in the diagnosis, risk assessment and effective targeted therapy.
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spelling pubmed-22591902009-09-10 Clinical implications of mutational analysis in gastrointestinal stromal tumours Hoeben, A Schöffski, P Debiec-Rychter, M Br J Cancer Minireview The management of localised and advanced gastrointestinal stromal tumours (GISTs) in terms of histological diagnosis, surgery, imaging, medical treatment and molecular biology has rapidly changed since introduction of imatinib mesylate for molecularly targeted therapy in 2000. In this minireview, we briefly summarise and discuss the current data relevant to the increasing role of molecular characterisation of GISTs in the diagnosis, risk assessment and effective targeted therapy. Nature Publishing Group 2008-02-26 2008-02-05 /pmc/articles/PMC2259190/ /pubmed/18253129 http://dx.doi.org/10.1038/sj.bjc.6604217 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Hoeben, A
Schöffski, P
Debiec-Rychter, M
Clinical implications of mutational analysis in gastrointestinal stromal tumours
title Clinical implications of mutational analysis in gastrointestinal stromal tumours
title_full Clinical implications of mutational analysis in gastrointestinal stromal tumours
title_fullStr Clinical implications of mutational analysis in gastrointestinal stromal tumours
title_full_unstemmed Clinical implications of mutational analysis in gastrointestinal stromal tumours
title_short Clinical implications of mutational analysis in gastrointestinal stromal tumours
title_sort clinical implications of mutational analysis in gastrointestinal stromal tumours
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259190/
https://www.ncbi.nlm.nih.gov/pubmed/18253129
http://dx.doi.org/10.1038/sj.bjc.6604217
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