Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma

Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence inte...

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Autores principales: Früh, M, Zhou, W, Zhai, R, Su, L, Heist, R S, Wain, J C, Nishioka, N S, Lynch, T J, Shepherd, F A, Christiani, D C, Liu, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259195/
https://www.ncbi.nlm.nih.gov/pubmed/18253117
http://dx.doi.org/10.1038/sj.bjc.6604234
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author Früh, M
Zhou, W
Zhai, R
Su, L
Heist, R S
Wain, J C
Nishioka, N S
Lynch, T J
Shepherd, F A
Christiani, D C
Liu, G
author_facet Früh, M
Zhou, W
Zhai, R
Su, L
Heist, R S
Wain, J C
Nishioka, N S
Lynch, T J
Shepherd, F A
Christiani, D C
Liu, G
author_sort Früh, M
collection PubMed
description Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1–0.7). Matrix metalloproteinases may modulate the EA–HP relationship.
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spelling pubmed-22591952009-09-10 Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma Früh, M Zhou, W Zhai, R Su, L Heist, R S Wain, J C Nishioka, N S Lynch, T J Shepherd, F A Christiani, D C Liu, G Br J Cancer Short Communication Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1–0.7). Matrix metalloproteinases may modulate the EA–HP relationship. Nature Publishing Group 2008-02-26 2008-02-05 /pmc/articles/PMC2259195/ /pubmed/18253117 http://dx.doi.org/10.1038/sj.bjc.6604234 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Früh, M
Zhou, W
Zhai, R
Su, L
Heist, R S
Wain, J C
Nishioka, N S
Lynch, T J
Shepherd, F A
Christiani, D C
Liu, G
Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
title Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
title_full Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
title_fullStr Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
title_full_unstemmed Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
title_short Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
title_sort polymorphisms of inflammatory and metalloproteinase genes, helicobacter pylori infection and the risk of oesophageal adenocarcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259195/
https://www.ncbi.nlm.nih.gov/pubmed/18253117
http://dx.doi.org/10.1038/sj.bjc.6604234
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