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Polyamine depletion induces G(1 )and S phase arrest in human retinoblastoma Y79 cells
BACKGROUND: Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G(1 )arrest through dephosphorylation of retinoblastoma protein (pRb). The effect of DFMO on cell growth of pRb deficient cells is...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259317/ https://www.ncbi.nlm.nih.gov/pubmed/18208615 http://dx.doi.org/10.1186/1475-2867-8-2 |