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Polyamine depletion induces G(1 )and S phase arrest in human retinoblastoma Y79 cells

BACKGROUND: Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G(1 )arrest through dephosphorylation of retinoblastoma protein (pRb). The effect of DFMO on cell growth of pRb deficient cells is...

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Detalles Bibliográficos
Autores principales:	Ueda, Akiko, Araie, Makoto, Kubota, Shunichiro
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259317/ https://www.ncbi.nlm.nih.gov/pubmed/18208615 http://dx.doi.org/10.1186/1475-2867-8-2

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