RNA interference: a multifaceted innate antiviral defense

The RNA interference mechanism utilizes short RNA duplexes to either suppress or induce target gene expression. Post-transcriptional regulation mediated by microRNA is an integral component of innate antiviral defense. The magnitude and the efficiency of viral restriction guided by RNA-based defense...

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Detalles Bibliográficos
Autor principal: Kumar, Ajit
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259359/
https://www.ncbi.nlm.nih.gov/pubmed/18241347
http://dx.doi.org/10.1186/1742-4690-5-17
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author Kumar, Ajit
author_facet Kumar, Ajit
author_sort Kumar, Ajit
collection PubMed
description The RNA interference mechanism utilizes short RNA duplexes to either suppress or induce target gene expression. Post-transcriptional regulation mediated by microRNA is an integral component of innate antiviral defense. The magnitude and the efficiency of viral restriction guided by RNA-based defenses, as well as the full physiological implication of host-pathogen engagement, constitute exciting areas of investigation in the biology of non-coding RNAs.
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spelling pubmed-22593592008-03-04 RNA interference: a multifaceted innate antiviral defense Kumar, Ajit Retrovirology Commentary The RNA interference mechanism utilizes short RNA duplexes to either suppress or induce target gene expression. Post-transcriptional regulation mediated by microRNA is an integral component of innate antiviral defense. The magnitude and the efficiency of viral restriction guided by RNA-based defenses, as well as the full physiological implication of host-pathogen engagement, constitute exciting areas of investigation in the biology of non-coding RNAs. BioMed Central 2008-02-01 /pmc/articles/PMC2259359/ /pubmed/18241347 http://dx.doi.org/10.1186/1742-4690-5-17 Text en Copyright © 2008 Kumar; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Kumar, Ajit
RNA interference: a multifaceted innate antiviral defense
title RNA interference: a multifaceted innate antiviral defense
title_full RNA interference: a multifaceted innate antiviral defense
title_fullStr RNA interference: a multifaceted innate antiviral defense
title_full_unstemmed RNA interference: a multifaceted innate antiviral defense
title_short RNA interference: a multifaceted innate antiviral defense
title_sort rna interference: a multifaceted innate antiviral defense
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259359/
https://www.ncbi.nlm.nih.gov/pubmed/18241347
http://dx.doi.org/10.1186/1742-4690-5-17
work_keys_str_mv AT kumarajit rnainterferenceamultifacetedinnateantiviraldefense

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