Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors

Metabotropic glutamate receptors (mGluRs) are G protein coupled receptors that play important roles in synaptic plasticity and other neuro-physiological and pathological processes. Allosteric mGluR ligands are particularly promising drug targets because of their modulatory effects – enhancing or sup...

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Detalles Bibliográficos
Autores principales: Yanamala, Naveena, Tirupula, Kalyan C, Klein-Seetharaman, Judith
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259417/
https://www.ncbi.nlm.nih.gov/pubmed/18315847
http://dx.doi.org/10.1186/1471-2105-9-S1-S16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259417/
https://www.ncbi.nlm.nih.gov/pubmed/18315847
http://dx.doi.org/10.1186/1471-2105-9-S1-S16

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