Cargando…

Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors

Metabotropic glutamate receptors (mGluRs) are G protein coupled receptors that play important roles in synaptic plasticity and other neuro-physiological and pathological processes. Allosteric mGluR ligands are particularly promising drug targets because of their modulatory effects – enhancing or sup...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yanamala, Naveena, Tirupula, Kalyan C, Klein-Seetharaman, Judith
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259417/ https://www.ncbi.nlm.nih.gov/pubmed/18315847 http://dx.doi.org/10.1186/1471-2105-9-S1-S16

Ejemplares similares

Allosteric Modulation of G Protein Coupled Receptors by Cytoplasmic, Transmembrane and Extracellular Ligands
por: Yanamala, Naveena, et al.
Publicado: (2010)

Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2
por: Liauw, Brandon Wey-Hung, et al.
Publicado: (2022)

Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor
por: Gutzeit, Vanessa A, et al.
Publicado: (2019)

Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
por: Nasrallah, Chady, et al.
Publicado: (2021)

Allosteric Molecular Switches in Metabotropic Glutamate Receptors
por: Orgován, Zoltán, et al.
Publicado: (2020)

Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease
por: Luessen, Deborah J., et al.
Publicado: (2022)

Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling
por: Tresadern, Gary, et al.
Publicado: (2017)

Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
por: Kampen, Stefanie, et al.
Publicado: (2022)

A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors
por: Moitra, Subhodeep, et al.
Publicado: (2012)

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants
por: Harpsøe, Kasper, et al.
Publicado: (2015)

Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window
por: Mihov, Yoan, et al.
Publicado: (2016)

Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma
por: Wirsching, Hans-Georg, et al.
Publicado: (2020)

Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
por: Mitchell, James, et al.
Publicado: (2019)

Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
por: Mitchell, James, et al.
Publicado: (2019)

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
por: Turlington, Mark, et al.
Publicado: (2014)

Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease
por: Doria, JG, et al.
Publicado: (2013)

In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5
por: Beggiato, Sarah, et al.
Publicado: (2018)

Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand
por: Dalton, James A. R., et al.
Publicado: (2017)

Conformational rearrangement during activation of a metabotropic glutamate receptor
por: Liauw, Brandon Wey-Hung, et al.
Publicado: (2021)

Concerted conformational changes control metabotropic glutamate receptor activity
por: Lecat-Guillet, Nathalie, et al.
Publicado: (2023)

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells
por: Volpi, Claudia, et al.
Publicado: (2016)

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization
por: Doornbos, Maarten L. J., et al.
Publicado: (2018)

Therapeutic Potential of Metabotropic Glutamate Receptor Modulators
por: Hovelsø, N, et al.
Publicado: (2012)

Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators
por: Fernández-Dueñas, Víctor, et al.
Publicado: (2020)

Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors
por: Pereira, Vanessa, et al.
Publicado: (2019)

Recent Advances in the Modulation of Pain by the Metabotropic Glutamate Receptors
por: Mazzitelli, Mariacristina, et al.
Publicado: (2022)

Investigation of allosteric modulation mechanism of metabotropic glutamate receptor 1 by molecular dynamics simulations, free energy and weak interaction analysis
por: Bai, Qifeng, et al.
Publicado: (2016)

Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor
por: de Lucas, Ana I., et al.
Publicado: (2021)

Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson’s Disease
por: Epping-Jordan, Mark P., et al.
Publicado: (2023)

A mixture of feature experts approach for protein-protein interaction prediction
por: Qi, Yanjun, et al.
Publicado: (2007)

Differential Dynamics of Extracellular and Cytoplasmic Domains in Denatured States of Rhodopsin
por: Dutta, Arpana, et al.
Publicado: (2014)

Designing allosteric modulators for active conformational state of m-glutamate G-protein coupled receptors
por: Omer, Ankur, et al.
Publicado: (2012)

Transmembrane helix prediction using amino acid property features and latent semantic analysis
por: Ganapathiraju, Madhavi, et al.
Publicado: (2008)

Alternative paths in HIV-1 targeted human signal transduction pathways
por: Balakrishnan, Sivaraman, et al.
Publicado: (2009)

Positive Allosteric Modulators of Type 5 Metabotropic Glutamate Receptors (mGluR5) and Their Therapeutic Potential for the Treatment of CNS Disorders
por: Cleva, Richard M., et al.
Publicado: (2011)

Biphasic Modulation of NMDA Receptor Function by Metabotropic Glutamate Receptors
por: O'Neill, Nathanael, et al.
Publicado: (2018)

Metabotropic glutamate receptors inhibit microglial glutamate release
por: McMullan, Stephen M, et al.
Publicado: (2012)

Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine
por: Kufahl, Peter R, et al.
Publicado: (2013)

Population Pharmacokinetic and Exposure–dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients
por: Cosson, Valérie, et al.
Publicado: (2018)

Optical Control of Metabotropic Glutamate Receptors
por: Levitz, Joshua, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_n0ihhh2t5qgtku9n2o9au54on7