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Stability of the core domain of p53: insights from computer simulations
BACKGROUND: The tumour suppressor protein p53 protein has a core domain that binds DNA and is the site for most oncogenic mutations. This domain is quite unstable compared to its homologs p63 and p73. Two key residues in the core domain of p53 (Tyr236, Thr253), have been mutated in-silico, to their...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259418/ https://www.ncbi.nlm.nih.gov/pubmed/18315848 http://dx.doi.org/10.1186/1471-2105-9-S1-S17 |