Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair

Retroviral transduction involves integrase-dependent linkage of viral and host DNA that leaves an intermediate that requires post-integration repair (PIR). We and others proposed that PIR hijacks the host cell double-strand DNA break (DSB) repair pathways. Nevertheless, the geometry of retroviral DN...

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Detalles Bibliográficos
Autores principales: Smith, Johanna A, Wang, Feng-Xiang, Zhang, Hui, Wu, Kou-Juey, Williams, Kevin Jon, Daniel, René
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262065/
https://www.ncbi.nlm.nih.gov/pubmed/18211700
http://dx.doi.org/10.1186/1743-422X-5-11

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