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Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig

BACKGROUND: Cough reflex can be induced by the pepper extract capsaicin and by low pH in guinea-pig airways. Transient receptor potential vanniloid-1 (TPRV-1) is expressed in the sensory and afferent nerve fibres in airways. OBJECTIVE: We hypothesized that a novel pyridazinylpiperazine analog TPRV-1...

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Detalles Bibliográficos
Autores principales:	Leung, Sum Yee, Niimi, Akio, Williams, Alison S, Nath, Puneeta, Blanc, F-Xavier, Dinh, Q Thai, Chung, K Fan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262090/ https://www.ncbi.nlm.nih.gov/pubmed/18154688 http://dx.doi.org/10.1186/1745-9974-3-10

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