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The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae
BACKGROUND: The corn smut fungus Ustilago maydis is a well-established model system for molecular phytopathology. In addition, it recently became evident that U. maydis and humans share proteins and cellular processes that are not found in the standard fungal model Saccharomyces cerevisiae. This pro...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262911/ https://www.ncbi.nlm.nih.gov/pubmed/18096044 http://dx.doi.org/10.1186/1471-2164-8-473 |
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author | Münsterkötter, Martin Steinberg, Gero |
author_facet | Münsterkötter, Martin Steinberg, Gero |
author_sort | Münsterkötter, Martin |
collection | PubMed |
description | BACKGROUND: The corn smut fungus Ustilago maydis is a well-established model system for molecular phytopathology. In addition, it recently became evident that U. maydis and humans share proteins and cellular processes that are not found in the standard fungal model Saccharomyces cerevisiae. This prompted us to do a comparative analysis of the predicted proteome of U. maydis, S. cerevisiae and humans. RESULTS: At a cut off at 20% identity over protein length, all three organisms share 1738 proteins, whereas both fungi share only 541 conserved proteins. Despite the evolutionary distance between U. maydis and humans, 777 proteins were shared. When applying a more stringent criterion (≥ 20% identity with a homologue in one organism over at least 50 amino acids and ≥ 10% less in the other organism), we found 681 proteins for the comparison of U. maydis and humans, whereas the both fungi share only 622 fungal specific proteins. Finally, we found that S. cerevisiae and humans shared 312 proteins. In the U. maydis to H. sapiens homology set 454 proteins are functionally classified and 42 proteins are related to serious human diseases. However, a large portion of 222 proteins are of unknown function. CONCLUSION: The fungus U. maydis has a long history of being a model system for understanding DNA recombination and repair, as well as molecular plant pathology. The identification of functionally un-characterized genes that are conserved in humans and U. maydis opens the door for experimental work, which promises new insight in the cell biology of the mammalian cell. |
format | Text |
id | pubmed-2262911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22629112008-03-05 The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae Münsterkötter, Martin Steinberg, Gero BMC Genomics Research Article BACKGROUND: The corn smut fungus Ustilago maydis is a well-established model system for molecular phytopathology. In addition, it recently became evident that U. maydis and humans share proteins and cellular processes that are not found in the standard fungal model Saccharomyces cerevisiae. This prompted us to do a comparative analysis of the predicted proteome of U. maydis, S. cerevisiae and humans. RESULTS: At a cut off at 20% identity over protein length, all three organisms share 1738 proteins, whereas both fungi share only 541 conserved proteins. Despite the evolutionary distance between U. maydis and humans, 777 proteins were shared. When applying a more stringent criterion (≥ 20% identity with a homologue in one organism over at least 50 amino acids and ≥ 10% less in the other organism), we found 681 proteins for the comparison of U. maydis and humans, whereas the both fungi share only 622 fungal specific proteins. Finally, we found that S. cerevisiae and humans shared 312 proteins. In the U. maydis to H. sapiens homology set 454 proteins are functionally classified and 42 proteins are related to serious human diseases. However, a large portion of 222 proteins are of unknown function. CONCLUSION: The fungus U. maydis has a long history of being a model system for understanding DNA recombination and repair, as well as molecular plant pathology. The identification of functionally un-characterized genes that are conserved in humans and U. maydis opens the door for experimental work, which promises new insight in the cell biology of the mammalian cell. BioMed Central 2007-12-20 /pmc/articles/PMC2262911/ /pubmed/18096044 http://dx.doi.org/10.1186/1471-2164-8-473 Text en Copyright © 2007 Münsterkötter and Steinberg; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Münsterkötter, Martin Steinberg, Gero The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae |
title | The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae |
title_full | The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae |
title_fullStr | The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae |
title_full_unstemmed | The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae |
title_short | The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae |
title_sort | fungus ustilago maydis and humans share disease-related proteins that are not found in saccharomyces cerevisiae |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262911/ https://www.ncbi.nlm.nih.gov/pubmed/18096044 http://dx.doi.org/10.1186/1471-2164-8-473 |
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