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Association of a Bovine Prion Gene Haplotype with Atypical BSE
BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS:...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2263129/ https://www.ncbi.nlm.nih.gov/pubmed/18350166 http://dx.doi.org/10.1371/journal.pone.0001830 |
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author | Clawson, Michael L. Richt, Juergen A. Baron, Thierry Biacabe, Anne-Gaëlle Czub, Stefanie Heaton, Michael P. Smith, Timothy P. L. Laegreid, William W. |
author_facet | Clawson, Michael L. Richt, Juergen A. Baron, Thierry Biacabe, Anne-Gaëlle Czub, Stefanie Heaton, Michael P. Smith, Timothy P. L. Laegreid, William W. |
author_sort | Clawson, Michael L. |
collection | PubMed |
description | BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS: Haplotype tagging polymorphisms that characterize PRNP haplotypes from the promoter region through the three prime untranslated region of exon 3 (25.2 kb) were used to determine PRNP haplotypes of six available atypical BSE cases from Canada, France and the United States. One or two copies of a distinct PRNP haplotype were identified in five of the six cases (p = 1.3×10(−4), two-tailed Fisher's exact test; CI(95%) 0.263–0.901, difference between proportions). The haplotype spans a portion of PRNP that includes part of intron 2, the entire coding region of exon 3 and part of the three prime untranslated region of exon 3 (13 kb). CONCLUSIONS/SIGNIFICANCE: This result suggests that a genetic determinant in or near PRNP may influence susceptibility of cattle to atypical BSE. |
format | Text |
id | pubmed-2263129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-22631292008-03-19 Association of a Bovine Prion Gene Haplotype with Atypical BSE Clawson, Michael L. Richt, Juergen A. Baron, Thierry Biacabe, Anne-Gaëlle Czub, Stefanie Heaton, Michael P. Smith, Timothy P. L. Laegreid, William W. PLoS One Research Article BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS: Haplotype tagging polymorphisms that characterize PRNP haplotypes from the promoter region through the three prime untranslated region of exon 3 (25.2 kb) were used to determine PRNP haplotypes of six available atypical BSE cases from Canada, France and the United States. One or two copies of a distinct PRNP haplotype were identified in five of the six cases (p = 1.3×10(−4), two-tailed Fisher's exact test; CI(95%) 0.263–0.901, difference between proportions). The haplotype spans a portion of PRNP that includes part of intron 2, the entire coding region of exon 3 and part of the three prime untranslated region of exon 3 (13 kb). CONCLUSIONS/SIGNIFICANCE: This result suggests that a genetic determinant in or near PRNP may influence susceptibility of cattle to atypical BSE. Public Library of Science 2008-03-19 /pmc/articles/PMC2263129/ /pubmed/18350166 http://dx.doi.org/10.1371/journal.pone.0001830 Text en This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Clawson, Michael L. Richt, Juergen A. Baron, Thierry Biacabe, Anne-Gaëlle Czub, Stefanie Heaton, Michael P. Smith, Timothy P. L. Laegreid, William W. Association of a Bovine Prion Gene Haplotype with Atypical BSE |
title | Association of a Bovine Prion Gene Haplotype with Atypical BSE |
title_full | Association of a Bovine Prion Gene Haplotype with Atypical BSE |
title_fullStr | Association of a Bovine Prion Gene Haplotype with Atypical BSE |
title_full_unstemmed | Association of a Bovine Prion Gene Haplotype with Atypical BSE |
title_short | Association of a Bovine Prion Gene Haplotype with Atypical BSE |
title_sort | association of a bovine prion gene haplotype with atypical bse |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2263129/ https://www.ncbi.nlm.nih.gov/pubmed/18350166 http://dx.doi.org/10.1371/journal.pone.0001830 |
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