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Association of a Bovine Prion Gene Haplotype with Atypical BSE

BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS:...

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Autores principales: Clawson, Michael L., Richt, Juergen A., Baron, Thierry, Biacabe, Anne-Gaëlle, Czub, Stefanie, Heaton, Michael P., Smith, Timothy P. L., Laegreid, William W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2263129/
https://www.ncbi.nlm.nih.gov/pubmed/18350166
http://dx.doi.org/10.1371/journal.pone.0001830
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author Clawson, Michael L.
Richt, Juergen A.
Baron, Thierry
Biacabe, Anne-Gaëlle
Czub, Stefanie
Heaton, Michael P.
Smith, Timothy P. L.
Laegreid, William W.
author_facet Clawson, Michael L.
Richt, Juergen A.
Baron, Thierry
Biacabe, Anne-Gaëlle
Czub, Stefanie
Heaton, Michael P.
Smith, Timothy P. L.
Laegreid, William W.
author_sort Clawson, Michael L.
collection PubMed
description BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS: Haplotype tagging polymorphisms that characterize PRNP haplotypes from the promoter region through the three prime untranslated region of exon 3 (25.2 kb) were used to determine PRNP haplotypes of six available atypical BSE cases from Canada, France and the United States. One or two copies of a distinct PRNP haplotype were identified in five of the six cases (p = 1.3×10(−4), two-tailed Fisher's exact test; CI(95%) 0.263–0.901, difference between proportions). The haplotype spans a portion of PRNP that includes part of intron 2, the entire coding region of exon 3 and part of the three prime untranslated region of exon 3 (13 kb). CONCLUSIONS/SIGNIFICANCE: This result suggests that a genetic determinant in or near PRNP may influence susceptibility of cattle to atypical BSE.
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spelling pubmed-22631292008-03-19 Association of a Bovine Prion Gene Haplotype with Atypical BSE Clawson, Michael L. Richt, Juergen A. Baron, Thierry Biacabe, Anne-Gaëlle Czub, Stefanie Heaton, Michael P. Smith, Timothy P. L. Laegreid, William W. PLoS One Research Article BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS: Haplotype tagging polymorphisms that characterize PRNP haplotypes from the promoter region through the three prime untranslated region of exon 3 (25.2 kb) were used to determine PRNP haplotypes of six available atypical BSE cases from Canada, France and the United States. One or two copies of a distinct PRNP haplotype were identified in five of the six cases (p = 1.3×10(−4), two-tailed Fisher's exact test; CI(95%) 0.263–0.901, difference between proportions). The haplotype spans a portion of PRNP that includes part of intron 2, the entire coding region of exon 3 and part of the three prime untranslated region of exon 3 (13 kb). CONCLUSIONS/SIGNIFICANCE: This result suggests that a genetic determinant in or near PRNP may influence susceptibility of cattle to atypical BSE. Public Library of Science 2008-03-19 /pmc/articles/PMC2263129/ /pubmed/18350166 http://dx.doi.org/10.1371/journal.pone.0001830 Text en This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Clawson, Michael L.
Richt, Juergen A.
Baron, Thierry
Biacabe, Anne-Gaëlle
Czub, Stefanie
Heaton, Michael P.
Smith, Timothy P. L.
Laegreid, William W.
Association of a Bovine Prion Gene Haplotype with Atypical BSE
title Association of a Bovine Prion Gene Haplotype with Atypical BSE
title_full Association of a Bovine Prion Gene Haplotype with Atypical BSE
title_fullStr Association of a Bovine Prion Gene Haplotype with Atypical BSE
title_full_unstemmed Association of a Bovine Prion Gene Haplotype with Atypical BSE
title_short Association of a Bovine Prion Gene Haplotype with Atypical BSE
title_sort association of a bovine prion gene haplotype with atypical bse
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2263129/
https://www.ncbi.nlm.nih.gov/pubmed/18350166
http://dx.doi.org/10.1371/journal.pone.0001830
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