Cargando…

Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening

BACKGROUND: The propensity of compounds to produce adverse health effects in humans is generally evaluated using animal-based test methods. Such methods can be relatively expensive, low-throughput, and associated with pain suffered by the treated animals. In addition, differences in species biology...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Menghang, Huang, Ruili, Witt, Kristine L., Southall, Noel, Fostel, Jennifer, Cho, Ming-Hsuang, Jadhav, Ajit, Smith, Cynthia S., Inglese, James, Portier, Christopher J., Tice, Raymond R., Austin, Christopher P.
Formato:	Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265061/ https://www.ncbi.nlm.nih.gov/pubmed/18335092 http://dx.doi.org/10.1289/ehp.10727

Ejemplares similares

Profiling Environmental Chemicals for Activity in the Antioxidant Response Element Signaling Pathway Using a High Throughput Screening Approach
por: Shukla, Sunita J, et al.
Publicado: (2012)

Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential
por: Attene-Ramos, Matias S., et al.
Publicado: (2014)

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway
por: Xia, Menghang, et al.
Publicado: (2009)

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington’s Disease Model
por: Titus, Steven A, et al.
Publicado: (2012)

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors
por: Huang, Ruili, et al.
Publicado: (2011)

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology
por: Dranchak, Patricia K., et al.
Publicado: (2023)

Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays
por: Lynch, Caitlin, et al.
Publicado: (2019)

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade
por: Simeonov, Anton, et al.
Publicado: (2008)

Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage
por: Hsieh, Jui-Hua, et al.
Publicado: (2017)

Correction: Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage
por: Hsieh, Jui-Hua, et al.
Publicado: (2017)

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death
por: Zhu, Ping Jun, et al.
Publicado: (2009)

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
por: Huang, Ruili, et al.
Publicado: (2014)

Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data
por: Sand, Salomon, et al.
Publicado: (2016)

A Cell-Based β-Lactamase Reporter Gene Assay for the CREB Signaling Pathway
por: Xia, Menghang, et al.
Publicado: (2009)

Identification of Thyroid Hormone Receptor Active Compounds Using a Quantitative High-Throughput Screening Platform
por: Freitas, Jaime, et al.
Publicado: (2014)

A Grid Algorithm for High Throughput Fitting of Dose-Response Curve Data
por: Wang, Yuhong, et al.
Publicado: (2010)

MON-032 Identification of Estrogen-Related Receptor Alpha Inhibitors from the Tox21 10K Compound Collection
por: Lynch, Caitlin, et al.
Publicado: (2019)

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress
por: Thorne, Natasha, et al.
Publicado: (2016)

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells
por: Leister, Kristin P, et al.
Publicado: (2011)

Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor
por: Lynch, Caitlin, et al.
Publicado: (2015)

Identification of repurposed small molecule drugs for chordoma therapy
por: Xia, Menghang, et al.
Publicado: (2013)

Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor
por: Hsu, Chia-Wen, et al.
Publicado: (2014)

Comprehensive Characterization of Cytochrome P450 Isozyme Selectivity across Chemical Libraries
por: Veith, Henrike, et al.
Publicado: (2009)

Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study
por: Abdo, Nour, et al.
Publicado: (2015)

Comparison on Functional Assays for Gq-Coupled GPCRs by Measuring Inositol Monophospate-1 and Intracellular Calcium in 1536-Well Plate Format
por: Liu, Ke, et al.
Publicado: (2008)

Isotonic Regression Based-Method in Quantitative High-Throughput Screenings for Genotoxicity
por: Fujii, Yosuke, et al.
Publicado: (2015)

A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp
por: Bhattacharyya, Nisan, et al.
Publicado: (2014)

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics
por: Huang, Ruili, et al.
Publicado: (2019)

High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition
por: Krishna, Shagun, et al.
Publicado: (2022)

A High-Throughput Approach for Identification of Novel General Anesthetics
por: Lea, Wendy A., et al.
Publicado: (2009)

High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase
por: Goldin, Ehud, et al.
Publicado: (2012)

High-Throughput Screening to Predict Chemical-Assay Interference
por: Borrel, Alexandre, et al.
Publicado: (2020)

Identification of Angiogenesis Inhibitors Using a Co-culture Cell Model in a High-Content and High-Throughput Screening Platform
por: Li, Shuaizhang, et al.
Publicado: (2017)

Bioactivity Signatures of Drugs vs. Environmental Chemicals Revealed by Tox21 High-Throughput Screening Assays
por: Ngan, Deborah K., et al.
Publicado: (2019)

A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2
por: Scoles, Daniel R., et al.
Publicado: (2022)

Deconstructing the Translational Tower of Babel
por: Austin, Christopher P., et al.
Publicado: (2018)

Identification of Compounds for Butyrylcholinesterase Inhibition
por: Li, Shuaizhang, et al.
Publicado: (2021)

Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens
por: Sun, Wei, et al.
Publicado: (2013)

Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements
por: Hubbard, Troy D., et al.
Publicado: (2019)

qHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data
por: Queme, Bryan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_udmo1kj87rhnnfen6pjnn39ltq