Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development

Mutations in the extracellular signal-regulated kinase (ERK) pathway, particularly in the mitogen-activated protein kinase/ERK kinase (MEK) activator B-Raf, are associated with human tumorigenesis and genetic disorders. Hence, B-Raf is a prime target for molecule-based therapies, and understanding i...

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Detalles Bibliográficos
Autores principales: Galabova-Kovacs, Gergana, Catalanotti, Federica, Matzen, Dana, Reyes, Gloria X., Zezula, Jürgen, Herbst, Ruth, Silva, Alcino, Walter, Ingrid, Baccarini, Manuela
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265404/
https://www.ncbi.nlm.nih.gov/pubmed/18332218
http://dx.doi.org/10.1083/jcb.200709069

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