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C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging
Inclusions in the brain containing α-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood. We have developed a C. elegans model that makes it possible to monitor, in living animals, the formation o...
Autores principales: | van Ham, Tjakko J., Thijssen, Karen L., Breitling, Rainer, Hofstra, Robert M. W., Plasterk, Ronald H. A., Nollen, Ellen A. A. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265412/ https://www.ncbi.nlm.nih.gov/pubmed/18369446 http://dx.doi.org/10.1371/journal.pgen.1000027 |
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