Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms

The mammalian circadian clockwork is composed of a core PER/CRY feedback loop and additional interlocking loops. In particular, the ROR/REV/Bmal1 loop, consisting of ROR activators and REV-ERB repressors that regulate Bmal1 expression, is thought to “stabilize” core clock function. However, due to f...

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Detalles Bibliográficos
Autores principales: Liu, Andrew C., Tran, Hien G., Zhang, Eric E., Priest, Aaron A., Welsh, David K., Kay, Steve A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265523/
https://www.ncbi.nlm.nih.gov/pubmed/18454201
http://dx.doi.org/10.1371/journal.pgen.1000023

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