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Role of Duplicate Genes in Robustness against Deleterious Human Mutations
It is now widely recognized that robustness is an inherent property of biological systems [1],[2],[3]. The contribution of close sequence homologs to genetic robustness against null mutations has been previously demonstrated in simple organisms [4],[5]. In this paper we investigate in detail the con...
Autores principales: | Hsiao, Tzu-Lin, Vitkup, Dennis |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265532/ https://www.ncbi.nlm.nih.gov/pubmed/18369440 http://dx.doi.org/10.1371/journal.pgen.1000014 |
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