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The wages of CIN
Aneuploidy and chromosome instability (CIN) are hallmarks of the majority of solid tumors, but the relationship between them is not well understood. In this issue, Thompson and Compton (Thompson, S.L., and D.A. Compton. 2008. Examining the link between chromosomal instability and aneuploidy in human...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265563/ https://www.ncbi.nlm.nih.gov/pubmed/18283117 http://dx.doi.org/10.1083/jcb.200801030 |
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author | Yuen, Karen W. Desai, Arshad |
author_facet | Yuen, Karen W. Desai, Arshad |
author_sort | Yuen, Karen W. |
collection | PubMed |
description | Aneuploidy and chromosome instability (CIN) are hallmarks of the majority of solid tumors, but the relationship between them is not well understood. In this issue, Thompson and Compton (Thompson, S.L., and D.A. Compton. 2008. Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell. Biol. 180:665–672) investigate the mechanism of CIN in cancer cells and find that CIN arises primarily from defective kinetochore–spindle attachments that evade detection by the spindle checkpoint and persist into anaphase. They also explore the consequences of artificially elevating chromosome missegregation in otherwise karyotypically normal cells. Their finding that induced aneuploidy is rapidly selected against suggests that the persistence of aneuploid cells in tumors requires not only chromosome missegregation but also additional, as yet poorly defined events. |
format | Text |
id | pubmed-2265563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22655632008-08-25 The wages of CIN Yuen, Karen W. Desai, Arshad J Cell Biol Reviews Aneuploidy and chromosome instability (CIN) are hallmarks of the majority of solid tumors, but the relationship between them is not well understood. In this issue, Thompson and Compton (Thompson, S.L., and D.A. Compton. 2008. Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell. Biol. 180:665–672) investigate the mechanism of CIN in cancer cells and find that CIN arises primarily from defective kinetochore–spindle attachments that evade detection by the spindle checkpoint and persist into anaphase. They also explore the consequences of artificially elevating chromosome missegregation in otherwise karyotypically normal cells. Their finding that induced aneuploidy is rapidly selected against suggests that the persistence of aneuploid cells in tumors requires not only chromosome missegregation but also additional, as yet poorly defined events. The Rockefeller University Press 2008-02-25 /pmc/articles/PMC2265563/ /pubmed/18283117 http://dx.doi.org/10.1083/jcb.200801030 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Yuen, Karen W. Desai, Arshad The wages of CIN |
title | The wages of CIN |
title_full | The wages of CIN |
title_fullStr | The wages of CIN |
title_full_unstemmed | The wages of CIN |
title_short | The wages of CIN |
title_sort | wages of cin |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265563/ https://www.ncbi.nlm.nih.gov/pubmed/18283117 http://dx.doi.org/10.1083/jcb.200801030 |
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