Cargando…

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

Integrin-linked kinase (ILK) is a serine-threonine kinase and scaffold protein with well defined roles in focal adhesions in integrin-mediated cell adhesion, spreading, migration, and signaling. Using mass spectrometry–based proteomic approaches, we identify centrosomal and mitotic spindle proteins...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fielding, Andrew B., Dobreva, Iveta, McDonald, Paul C., Foster, Leonard J., Dedhar, Shoukat
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265580/ https://www.ncbi.nlm.nih.gov/pubmed/18283114 http://dx.doi.org/10.1083/jcb.200710074

Ejemplares similares

Integrin-Linked Kinase links Dynactin-1/Dynactin-2 with cortical Integrin receptors to orient the mitotic spindle relative to the substratum
por: Morris, Edward James, et al.
Publicado: (2015)

Integrin-Linked Kinase Regulates Interphase and Mitotic Microtubule Dynamics
por: Lim, Simin, et al.
Publicado: (2013)

New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis
por: McDonald, Paul C., et al.
Publicado: (2022)

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
por: Serrano, Isabel, et al.
Publicado: (2013)

Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes
por: Gaglio, Tirso, et al.
Publicado: (1997)

Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
por: Wu, Chuanyue, et al.
Publicado: (2001)

Integrin-Linked Kinase Is a Functional Mn(2+)-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation
por: Maydan, Mykola, et al.
Publicado: (2010)

Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism
por: Tan, Jacqueline, et al.
Publicado: (2019)

Sinup is essential for the integrity of centrosomes and mitotic spindles in zebrafish embryos
por: Yoo, Kyeong-Won, et al.
Publicado: (2017)

Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes
por: Terpstra, Leonieke, et al.
Publicado: (2003)

Stat3 in mitosis: A new role in clustering excess centrosomes
por: Morris, Edward J., et al.
Publicado: (2017)

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
por: Assi, Kiran, et al.
Publicado: (2011)

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells
por: Kawamura, Eiko, et al.
Publicado: (2013)

A dual role for integrin-linked kinase in platelets: regulating integrin function and α-granule secretion
por: Tucker, Katherine L., et al.
Publicado: (2008)

Centrosomal Actin Assembly Is Required for Proper Mitotic Spindle Formation and Chromosome Congression
por: Plessner, Matthias, et al.
Publicado: (2019)

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway
por: Contadini, Claudia, et al.
Publicado: (2019)

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration
por: Esfandiarei, Mitra, et al.
Publicado: (2010)

Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development
por: Oloumi, Arusha, et al.
Publicado: (2010)

Characterisation of integrin-linked kinase signalling in sporadic human colon cancer
por: Marotta, A, et al.
Publicado: (2003)

O-Linked N-Acetylglucosamine Cycling Regulates Mitotic Spindle Organization
por: Tan, Ee Phie, et al.
Publicado: (2013)

Perturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis
por: Reverte, Carlos G., et al.
Publicado: (2006)

Mitotic spindle formation in the absence of Polo kinase
por: Kim, Juyoung, et al.
Publicado: (2022)

Morphologically distinct microtubule ends in the mitotic centrosome of Caenorhabditis elegans
por: O'Toole, Eileen T., et al.
Publicado: (2003)

A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
por: Chavali, Pavithra L., et al.
Publicado: (2016)

Synergy between Multiple Microtubule-Generating Pathways Confers Robustness to Centrosome-Driven Mitotic Spindle Formation
por: Hayward, Daniel, et al.
Publicado: (2014)

Centrosome–nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity
por: Nunes, Vanessa, et al.
Publicado: (2020)

Mitotic Acetylation of Microtubules Promotes Centrosomal PLK1 Recruitment and Is Required to Maintain Bipolar Spindle Homeostasis
por: Rasamizafy, Sylvia Fenosoa, et al.
Publicado: (2021)

The APC/C targets the Cep152–Cep63 complex at the centrosome to regulate mitotic spindle assembly
por: Tischer, Thomas, et al.
Publicado: (2022)

Regulation of Mitotic Cytoskeleton Dynamics and Cytokinesis by Integrin-Linked Kinase in Retinoblastoma Cells
por: Sikkema, William K. A., et al.
Publicado: (2014)

Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK)
por: Santos, Nancy Dos, et al.
Publicado: (2007)

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation
por: Whalley, Helen J., et al.
Publicado: (2015)

SH2D4A promotes centrosome maturation to support spindle microtubule formation and mitotic progression
por: Yuki, Ryuzaburo, et al.
Publicado: (2023)

Think globally, act locally: Centrosome-localized mRNAs ensure mitotic fidelity
por: Zarnescu, Daniela C.
Publicado: (2020)

A requirement for epsin in mitotic membrane and spindle organization
por: Liu, Zhonghua, et al.
Publicado: (2009)

Self-organization of kinetochore-fibers in human mitotic spindles
por: Conway, William, et al.
Publicado: (2022)

Concentrating on the mitotic spindle
por: Maddox, Paul S., et al.
Publicado: (2015)

A requirement for MAP kinase in the assembly and maintenance of the mitotic spindle
por: Horne, Melinda M., et al.
Publicado: (2003)

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
por: Morris, Edward J., et al.
Publicado: (2017)

Drosophila Xpd Regulates Cdk7 Localization, Mitotic Kinase Activity, Spindle Dynamics, and Chromosome Segregation
por: Li, Xiaoming, et al.
Publicado: (2010)

Structural Basis for Mitotic Centrosome Assembly in Flies
por: Feng, Zhe, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bl397n7d9iaee3o1u9ov1c1us2