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Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy
BACKGROUND: Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs. RESULTS: Here, we demonstrate that PI3K/Akt inhibitors, including clinically available Miltefosine, dramatically reduced HIV-1 p...
Autores principales: | Chugh, Pauline, Bradel-Tretheway, Birgit, Monteiro-Filho, Carlos MR, Planelles, Vicente, Maggirwar, Sanjay B, Dewhurst, Stephen, Kim, Baek |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265748/ https://www.ncbi.nlm.nih.gov/pubmed/18237430 http://dx.doi.org/10.1186/1742-4690-5-11 |
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