Cargando…

The Glutamate Transporter Subtypes EAAT4 and EAATs 1-3 Transport Glutamate with Dramatically Different Kinetics and Voltage Dependence but Share a Common Uptake Mechanism

Here, we report the application of glutamate concentration jumps and voltage jumps to determine the kinetics of rapid reaction steps of excitatory amino acid transporter subtype 4 (EAAT4) with a 100-μs time resolution. EAAT4 was expressed in HEK293 cells, and the electrogenic transport and anion cur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mim, Carsten, Balani, Poonam, Rauen, Thomas, Grewer, Christof
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266596/ https://www.ncbi.nlm.nih.gov/pubmed/16316976 http://dx.doi.org/10.1085/jgp.200509365

Ejemplares similares

Glutamate Transporters EAAT4 and EAAT5 Are Expressed in Vestibular Hair Cells and Calyx Endings
por: Dalet, Antoine, et al.
Publicado: (2012)

Excitatory Amino Acid Transporters (EAATs): Glutamate Transport and Beyond
por: Magi, Simona, et al.
Publicado: (2019)

Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders
por: Parkin, Georgia M, et al.
Publicado: (2018)

Molecular Dynamics Simulations of the Mammalian Glutamate Transporter EAAT3
por: Heinzelmann, Germano, et al.
Publicado: (2014)

The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder
por: Escobar, Angélica P., et al.
Publicado: (2019)

Effects of tranexamic acid on the activity of glutamate transporter EAAT3
por: Shin, Hyun-Jung, et al.
Publicado: (2020)

EAAT5 Glutamate Transporter-Mediated Inhibition in the Vertebrate Retina
por: Lukasiewcz, Peter D., et al.
Publicado: (2021)

Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell Terminals
por: Tang, Fu-Sheng, et al.
Publicado: (2022)

LRET-based distance measurements in the mammalian glutamate transporter EAAT3
por: Saha, Kusumika, et al.
Publicado: (2012)

Impaired K(+) binding to glial glutamate transporter EAAT1 in migraine
por: Kovermann, Peter, et al.
Publicado: (2017)

Shaping of Signal Transmission at the Photoreceptor Synapse by EAAT2 Glutamate Transporters
por: Niklaus, Stephanie, et al.
Publicado: (2017)

Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice
por: González, Luis F., et al.
Publicado: (2017)

Effects of clonidine on the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes
por: Woo, Jae Hee, et al.
Publicado: (2012)

Polymorphism of the Glutamate Transporter Protein EAAT2 and Migraine Transformation into Chronic Daily Headache
por: Shin, Hae-Eun, et al.
Publicado: (2011)

Position of the Third Na(+) Site in the Aspartate Transporter Glt(Ph) and the Human Glutamate Transporter, EAAT1
por: Bastug, Turgut, et al.
Publicado: (2012)

Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System x(c)(−)
por: Bridges, Richard J., et al.
Publicado: (2008)

Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants
por: Rajatileka, Shavanthi, et al.
Publicado: (2017)

Remote Ischaemic Preconditioning Accelerates Brain to Blood Glutamate Efflux via EAATs-mediated Transport
por: Končekova, Jana, et al.
Publicado: (2023)

The Accessibility in the External Part of the TM5 of the Glutamate Transporter EAAT1 Is Conformationally Sensitive during the Transport Cycle
por: Zhang, Xiuping, et al.
Publicado: (2012)

Klotho Sensitivity of the Neuronal Excitatory Amino Acid Transporters EAAT3 and EAAT4
por: Almilaji, Ahmad, et al.
Publicado: (2013)

Doxepin and imipramine but not fluoxetine reduce the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes
por: Park, Hye Jin, et al.
Publicado: (2015)

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease
por: Takahashi, Kou, et al.
Publicado: (2015)

Blood glutamate EAAT(2)-cell grabbing therapy in cerebral ischemia
por: Pérez-Mato, María, et al.
Publicado: (2018)

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2
por: Hinson, Shannon R., et al.
Publicado: (2008)

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells
por: Perkins, Emma M, et al.
Publicado: (2018)

Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
por: Hotz, Adriana L., et al.
Publicado: (2021)

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease
por: Perrin, Florian, et al.
Publicado: (2023)

Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity
por: Pajarillo, Edward, et al.
Publicado: (2021)

Cysteine Transport through Excitatory Amino Acid Transporter 3 (EAAT3)
por: Watts, Spencer D., et al.
Publicado: (2014)

A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke
por: Mallolas, Judith, et al.
Publicado: (2006)

The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells
por: Ching, Jared, et al.
Publicado: (2015)

Excitatory Amino Acid Transporter EAAT5 Improves Temporal Resolution in the Retina
por: Gehlen, Jana, et al.
Publicado: (2021)

Mechanism and potential sites of potassium interaction with glutamate transporters
por: Wang, Jiali, et al.
Publicado: (2020)

EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells
por: Ye, Jin-ling, et al.
Publicado: (2016)

Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2
por: Kato, Takafumi, et al.
Publicado: (2022)

MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro
por: Wei, Ya Bin, et al.
Publicado: (2016)

Modulation of Glutamate Transporter EAAT1 and Inward-Rectifier Potassium Channel K(ir4.1) Expression in Cultured Spinal Cord Astrocytes by Platinum-Based Chemotherapeutics
por: Leo, Markus, et al.
Publicado: (2021)

Gateways for Glutamate Neuroprotection in Parkinson’s Disease (PD): Essential Role of EAAT3 and NCX1 Revealed in an In Vitro Model of PD
por: Piccirillo, Silvia, et al.
Publicado: (2020)

Estrogen and progesterone attenuate glutamate neurotoxicity via regulation of EAAT3 and GLT-1 in a rat model of ischemic stroke
por: Nematipour, Sara, et al.
Publicado: (2020)

Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2a
por: Hentig, James, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2si7niv7cmmlme7p1g7qedpnr2