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Defining the Retinoid Binding Site in the Rod Cyclic Nucleotide-gated Channel

Rod vision is initiated when 11-cis-retinal, bound within rhodopsin, absorbs a photon and isomerizes to all-trans-retinal (ATR). This triggers an enzyme cascade that lowers cGMP, thereby closing cyclic nucleotide-gated (CNG) channels. ATR then dissociates from rhodopsin, with bright light releasing...

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Detalles Bibliográficos
Autores principales:	Horrigan, Diana M., Tetreault, Michelle L., Tsomaia, Natia, Vasileiou, Chrysoula, Borhan, Babak, Mierke, Dale F., Crouch, Rosalie K., Zimmerman, Anita L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266610/ https://www.ncbi.nlm.nih.gov/pubmed/16230468 http://dx.doi.org/10.1085/jgp.200509387

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