Initial Coupling of Binding to Gating Mediated by Conserved Residues in the Muscle Nicotinic Receptor

We examined functional consequences of intrasubunit contacts in the nicotinic receptor α subunit using single channel kinetic analysis, site-directed mutagenesis, and structural modeling. At the periphery of the ACh binding site, our structural model shows that side chains of the conserved residues...

Descripción completa

Detalles Bibliográficos
Autores principales: Mukhtasimova, Nuriya, Free, Chris, Sine, Steven M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266616/
https://www.ncbi.nlm.nih.gov/pubmed/15955875
http://dx.doi.org/10.1085/jgp.200509283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266616/
https://www.ncbi.nlm.nih.gov/pubmed/15955875
http://dx.doi.org/10.1085/jgp.200509283

Ejemplares similares