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Initial Coupling of Binding to Gating Mediated by Conserved Residues in the Muscle Nicotinic Receptor
We examined functional consequences of intrasubunit contacts in the nicotinic receptor α subunit using single channel kinetic analysis, site-directed mutagenesis, and structural modeling. At the periphery of the ACh binding site, our structural model shows that side chains of the conserved residues...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266616/ https://www.ncbi.nlm.nih.gov/pubmed/15955875 http://dx.doi.org/10.1085/jgp.200509283 |