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Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

BACKGROUND: Amyloid precursor protein (APP) is enzymatically cleaved by γ-secretase to form two peptide products, either Aβ40 or the more neurotoxic Aβ42. The Aβ42/40 ratio is increased in many cases of familial Alzheimer's disease (FAD). The transmembrane domain (TM) of APP contains the known...

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Detalles Bibliográficos
Autores principales:	Gorman, Paul M, Kim, Sanguk, Guo, Meng, Melnyk, Roman A, McLaurin, Joanne, Fraser, Paul E, Bowie, James U, Chakrabartty, Avijit
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266763/ https://www.ncbi.nlm.nih.gov/pubmed/18234110 http://dx.doi.org/10.1186/1471-2202-9-17

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