Cargando…
Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer
The phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266814/ https://www.ncbi.nlm.nih.gov/pubmed/18350121 http://dx.doi.org/10.1155/2008/392090 |
_version_ | 1782151568117727232 |
---|---|
author | Sakamoto, Keiichi Ohno-Okumura, Eiko Kato, Taku Watanabe, Masaki Cook, Michael J. |
author_facet | Sakamoto, Keiichi Ohno-Okumura, Eiko Kato, Taku Watanabe, Masaki Cook, Michael J. |
author_sort | Sakamoto, Keiichi |
collection | PubMed |
description | The phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products. All quaternized and sulfo-substituted showed amphiphilic character. Identical peaks in cyclic voltammograms appeared for these products before and after quaternization. During the evaluation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for its photodynamic therapy of cancer (PDT) efficacy by cancer cell culture, the light exposed dimethyl sulfate quaternized zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazines in IU-002 cells produce cell disruption that can be detected as a decrease in fluorescence. |
format | Text |
id | pubmed-2266814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22668142008-03-18 Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer Sakamoto, Keiichi Ohno-Okumura, Eiko Kato, Taku Watanabe, Masaki Cook, Michael J. Met Based Drugs Research Article The phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products. All quaternized and sulfo-substituted showed amphiphilic character. Identical peaks in cyclic voltammograms appeared for these products before and after quaternization. During the evaluation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for its photodynamic therapy of cancer (PDT) efficacy by cancer cell culture, the light exposed dimethyl sulfate quaternized zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazines in IU-002 cells produce cell disruption that can be detected as a decrease in fluorescence. Hindawi Publishing Corporation 2008 2008-02-26 /pmc/articles/PMC2266814/ /pubmed/18350121 http://dx.doi.org/10.1155/2008/392090 Text en Copyright © 2008 Keiichi Sakamoto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sakamoto, Keiichi Ohno-Okumura, Eiko Kato, Taku Watanabe, Masaki Cook, Michael J. Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer |
title | Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer |
title_full | Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer |
title_fullStr | Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer |
title_full_unstemmed | Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer |
title_short | Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer |
title_sort | investigation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for application as photosensitizer in photodynamic therapy of cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266814/ https://www.ncbi.nlm.nih.gov/pubmed/18350121 http://dx.doi.org/10.1155/2008/392090 |
work_keys_str_mv | AT sakamotokeiichi investigationofzincbis14didecylbenzobis23pyridoporphyrazineforapplicationasphotosensitizerinphotodynamictherapyofcancer AT ohnookumuraeiko investigationofzincbis14didecylbenzobis23pyridoporphyrazineforapplicationasphotosensitizerinphotodynamictherapyofcancer AT katotaku investigationofzincbis14didecylbenzobis23pyridoporphyrazineforapplicationasphotosensitizerinphotodynamictherapyofcancer AT watanabemasaki investigationofzincbis14didecylbenzobis23pyridoporphyrazineforapplicationasphotosensitizerinphotodynamictherapyofcancer AT cookmichaelj investigationofzincbis14didecylbenzobis23pyridoporphyrazineforapplicationasphotosensitizerinphotodynamictherapyofcancer |