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Population pharmacokinetic data analysis of three phase I studies of matuzumab, a humanised anti-EGFR monoclonal antibody in clinical cancer development

A population pharmacokinetic model based on data from three phase I studies was to be developed including a covariate analysis to describe the concentration–time profiles of matuzumab, a novel humanised monoclonal antibody. Matuzumab was administered as multiple 1 h i.v. infusions with 11 different...

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Detalles Bibliográficos
Autores principales: Kuester, K, Kovar, A, Lüpfert, C, Brockhaus, B, Kloft, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266843/
https://www.ncbi.nlm.nih.gov/pubmed/18319714
http://dx.doi.org/10.1038/sj.bjc.6604265