Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical e...

Descripción completa

Detalles Bibliográficos
Autores principales: Lemos, C, Jansen, G, Peters, G J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266858/
https://www.ncbi.nlm.nih.gov/pubmed/18253130
http://dx.doi.org/10.1038/sj.bjc.6604213
_version_ 1782151573532573696
author Lemos, C
Jansen, G
Peters, G J
author_facet Lemos, C
Jansen, G
Peters, G J
author_sort Lemos, C
collection PubMed
description Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors.
format Text
id pubmed-2266858
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-22668582009-09-10 Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors Lemos, C Jansen, G Peters, G J Br J Cancer Minireview Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors. Nature Publishing Group 2008-03-11 2008-02-05 /pmc/articles/PMC2266858/ /pubmed/18253130 http://dx.doi.org/10.1038/sj.bjc.6604213 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Lemos, C
Jansen, G
Peters, G J
Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors
title Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors
title_full Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors
title_fullStr Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors
title_full_unstemmed Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors
title_short Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors
title_sort drug transporters: recent advances concerning bcrp and tyrosine kinase inhibitors
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266858/
https://www.ncbi.nlm.nih.gov/pubmed/18253130
http://dx.doi.org/10.1038/sj.bjc.6604213
work_keys_str_mv AT lemosc drugtransportersrecentadvancesconcerningbcrpandtyrosinekinaseinhibitors
AT janseng drugtransportersrecentadvancesconcerningbcrpandtyrosinekinaseinhibitors
AT petersgj drugtransportersrecentadvancesconcerningbcrpandtyrosinekinaseinhibitors

Ejemplares similares