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Feeding Our Immune System: Impact on Metabolism

Endogenous intestinal microflora and environmental factors, such as diet, play a central role in immune homeostasis and reactivity. In addition, microflora and diet both influence body weight and insulin-resistance, notably through an action on adipose cells. Moreover, it is known since a long time...

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Autores principales: Wolowczuk, Isabelle, Verwaerde, Claudie, Viltart, Odile, Delanoye, Anne, Delacre, Myriam, Pot, Bruno, Grangette, Corinne
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266987/
https://www.ncbi.nlm.nih.gov/pubmed/18350123
http://dx.doi.org/10.1155/2008/639803
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author Wolowczuk, Isabelle
Verwaerde, Claudie
Viltart, Odile
Delanoye, Anne
Delacre, Myriam
Pot, Bruno
Grangette, Corinne
author_facet Wolowczuk, Isabelle
Verwaerde, Claudie
Viltart, Odile
Delanoye, Anne
Delacre, Myriam
Pot, Bruno
Grangette, Corinne
author_sort Wolowczuk, Isabelle
collection PubMed
description Endogenous intestinal microflora and environmental factors, such as diet, play a central role in immune homeostasis and reactivity. In addition, microflora and diet both influence body weight and insulin-resistance, notably through an action on adipose cells. Moreover, it is known since a long time that any disturbance in metabolism, like obesity, is associated with immune alteration, for example, inflammation. The purpose of this review is to provide an update on how nutrients-derived factors (mostly focusing on fatty acids and glucose) impact the innate and acquired immune systems, including the gut immune system and its associated bacterial flora. We will try to show the reader how the highly energy-demanding immune cells use glucose as a main source of fuel in a way similar to that of insulin-responsive adipose tissue and how Toll-like receptors (TLRs) of the innate immune system, which are found on immune cells, intestinal cells, and adipocytes, are presently viewed as essential actors in the complex balance ensuring bodily immune and metabolic health. Understanding more about these links will surely help to study and understand in a more fundamental way the common observation that eating healthy will keep you and your immune system healthy.
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spelling pubmed-22669872008-03-18 Feeding Our Immune System: Impact on Metabolism Wolowczuk, Isabelle Verwaerde, Claudie Viltart, Odile Delanoye, Anne Delacre, Myriam Pot, Bruno Grangette, Corinne Clin Dev Immunol Review Article Endogenous intestinal microflora and environmental factors, such as diet, play a central role in immune homeostasis and reactivity. In addition, microflora and diet both influence body weight and insulin-resistance, notably through an action on adipose cells. Moreover, it is known since a long time that any disturbance in metabolism, like obesity, is associated with immune alteration, for example, inflammation. The purpose of this review is to provide an update on how nutrients-derived factors (mostly focusing on fatty acids and glucose) impact the innate and acquired immune systems, including the gut immune system and its associated bacterial flora. We will try to show the reader how the highly energy-demanding immune cells use glucose as a main source of fuel in a way similar to that of insulin-responsive adipose tissue and how Toll-like receptors (TLRs) of the innate immune system, which are found on immune cells, intestinal cells, and adipocytes, are presently viewed as essential actors in the complex balance ensuring bodily immune and metabolic health. Understanding more about these links will surely help to study and understand in a more fundamental way the common observation that eating healthy will keep you and your immune system healthy. Hindawi Publishing Corporation 2008 2008-02-25 /pmc/articles/PMC2266987/ /pubmed/18350123 http://dx.doi.org/10.1155/2008/639803 Text en Copyright © 2008 Isabelle Wolowczuk et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wolowczuk, Isabelle
Verwaerde, Claudie
Viltart, Odile
Delanoye, Anne
Delacre, Myriam
Pot, Bruno
Grangette, Corinne
Feeding Our Immune System: Impact on Metabolism
title Feeding Our Immune System: Impact on Metabolism
title_full Feeding Our Immune System: Impact on Metabolism
title_fullStr Feeding Our Immune System: Impact on Metabolism
title_full_unstemmed Feeding Our Immune System: Impact on Metabolism
title_short Feeding Our Immune System: Impact on Metabolism
title_sort feeding our immune system: impact on metabolism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266987/
https://www.ncbi.nlm.nih.gov/pubmed/18350123
http://dx.doi.org/10.1155/2008/639803
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