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Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals

Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to b...

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Autores principales: Major-Pedersen, A., Ihlemann, N., Hermann, T. S., Christiansen, B., Dominguez, H., Kveiborg, B., Nielsen, D. B., Svendsen, O. L., Køber, L., Torp-Pedersen, C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266989/
https://www.ncbi.nlm.nih.gov/pubmed/18350125
http://dx.doi.org/10.1155/2008/672021
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author Major-Pedersen, A.
Ihlemann, N.
Hermann, T. S.
Christiansen, B.
Dominguez, H.
Kveiborg, B.
Nielsen, D. B.
Svendsen, O. L.
Køber, L.
Torp-Pedersen, C.
author_facet Major-Pedersen, A.
Ihlemann, N.
Hermann, T. S.
Christiansen, B.
Dominguez, H.
Kveiborg, B.
Nielsen, D. B.
Svendsen, O. L.
Køber, L.
Torp-Pedersen, C.
author_sort Major-Pedersen, A.
collection PubMed
description Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. Methods. We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. Results. The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 ± 1.41 (P = .009) and 2.34 ± 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. Conclusion. Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.
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spelling pubmed-22669892008-03-18 Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals Major-Pedersen, A. Ihlemann, N. Hermann, T. S. Christiansen, B. Dominguez, H. Kveiborg, B. Nielsen, D. B. Svendsen, O. L. Køber, L. Torp-Pedersen, C. Exp Diabetes Res Research Article Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. Methods. We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. Results. The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 ± 1.41 (P = .009) and 2.34 ± 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. Conclusion. Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load. Hindawi Publishing Corporation 2008 2008-03-04 /pmc/articles/PMC2266989/ /pubmed/18350125 http://dx.doi.org/10.1155/2008/672021 Text en Copyright © 2008 A. Major-Pedersen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Major-Pedersen, A.
Ihlemann, N.
Hermann, T. S.
Christiansen, B.
Dominguez, H.
Kveiborg, B.
Nielsen, D. B.
Svendsen, O. L.
Køber, L.
Torp-Pedersen, C.
Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals
title Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals
title_full Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals
title_fullStr Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals
title_full_unstemmed Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals
title_short Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals
title_sort effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266989/
https://www.ncbi.nlm.nih.gov/pubmed/18350125
http://dx.doi.org/10.1155/2008/672021
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