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Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals
Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to b...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266989/ https://www.ncbi.nlm.nih.gov/pubmed/18350125 http://dx.doi.org/10.1155/2008/672021 |
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author | Major-Pedersen, A. Ihlemann, N. Hermann, T. S. Christiansen, B. Dominguez, H. Kveiborg, B. Nielsen, D. B. Svendsen, O. L. Køber, L. Torp-Pedersen, C. |
author_facet | Major-Pedersen, A. Ihlemann, N. Hermann, T. S. Christiansen, B. Dominguez, H. Kveiborg, B. Nielsen, D. B. Svendsen, O. L. Køber, L. Torp-Pedersen, C. |
author_sort | Major-Pedersen, A. |
collection | PubMed |
description | Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. Methods. We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. Results. The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 ± 1.41 (P = .009) and 2.34 ± 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. Conclusion. Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load. |
format | Text |
id | pubmed-2266989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22669892008-03-18 Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals Major-Pedersen, A. Ihlemann, N. Hermann, T. S. Christiansen, B. Dominguez, H. Kveiborg, B. Nielsen, D. B. Svendsen, O. L. Køber, L. Torp-Pedersen, C. Exp Diabetes Res Research Article Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. Methods. We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. Results. The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 ± 1.41 (P = .009) and 2.34 ± 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. Conclusion. Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load. Hindawi Publishing Corporation 2008 2008-03-04 /pmc/articles/PMC2266989/ /pubmed/18350125 http://dx.doi.org/10.1155/2008/672021 Text en Copyright © 2008 A. Major-Pedersen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Major-Pedersen, A. Ihlemann, N. Hermann, T. S. Christiansen, B. Dominguez, H. Kveiborg, B. Nielsen, D. B. Svendsen, O. L. Køber, L. Torp-Pedersen, C. Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals |
title | Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals |
title_full | Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals |
title_fullStr | Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals |
title_full_unstemmed | Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals |
title_short | Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals |
title_sort | effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266989/ https://www.ncbi.nlm.nih.gov/pubmed/18350125 http://dx.doi.org/10.1155/2008/672021 |
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