Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

Type II hexokinase is overexpressed in most neoplastic cells, and it mainly localizes on the outer mitochondrial membrane. Hexokinase II dissociation from mitochondria triggers apoptosis. The prevailing model postulates that hexokinase II release from its mitochondrial interactor, the voltage-depend...

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Detalles Bibliográficos
Autores principales: Chiara, Federica, Castellaro, Diego, Marin, Oriano, Petronilli, Valeria, Brusilow, William S., Juhaszova, Magdalena, Sollott, Steven J., Forte, Michael, Bernardi, Paolo, Rasola, Andrea
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267038/
https://www.ncbi.nlm.nih.gov/pubmed/18350175
http://dx.doi.org/10.1371/journal.pone.0001852

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