Novel Carboranyl Derivatives of Nucleoside Mono- and Diphosphites and Phosphonates: A Synthetic Investigation

A number of nucleoside mono- and diphosphites and phosphonates containing 1,2-dicarbadodecaborane (12) (la-6b) at 5'-position of the sugar moiety have been synthesized in good yields. Experimental details along with the spectroscopic and analytical data, supporting the formation of the title co...

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Detalles Bibliográficos
Autores principales: Vyakaranam, Kamesh, Hosmane, Narayan S.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267069/
https://www.ncbi.nlm.nih.gov/pubmed/18365067
http://dx.doi.org/10.1155/S1565363304000032
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author Vyakaranam, Kamesh
Hosmane, Narayan S.
author_facet Vyakaranam, Kamesh
Hosmane, Narayan S.
author_sort Vyakaranam, Kamesh
collection PubMed
description A number of nucleoside mono- and diphosphites and phosphonates containing 1,2-dicarbadodecaborane (12) (la-6b) at 5'-position of the sugar moiety have been synthesized in good yields. Experimental details along with the spectroscopic and analytical data, supporting the formation of the title compounds, are presented. These constitute a new generation of boron compounds that are envisioned to be useful in cancer treatment via Boron Neutron Capture Therapy (BNCT).
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spelling pubmed-22670692008-03-24 Novel Carboranyl Derivatives of Nucleoside Mono- and Diphosphites and Phosphonates: A Synthetic Investigation Vyakaranam, Kamesh Hosmane, Narayan S. Bioinorg Chem Appl Research Article A number of nucleoside mono- and diphosphites and phosphonates containing 1,2-dicarbadodecaborane (12) (la-6b) at 5'-position of the sugar moiety have been synthesized in good yields. Experimental details along with the spectroscopic and analytical data, supporting the formation of the title compounds, are presented. These constitute a new generation of boron compounds that are envisioned to be useful in cancer treatment via Boron Neutron Capture Therapy (BNCT). Hindawi Publishing Corporation 2004 /pmc/articles/PMC2267069/ /pubmed/18365067 http://dx.doi.org/10.1155/S1565363304000032 Text en Copyright © 2004 Kamesh Vyakaranam and Narayan S. Hosmane. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vyakaranam, Kamesh
Hosmane, Narayan S.
Novel Carboranyl Derivatives of Nucleoside Mono- and Diphosphites and Phosphonates: A Synthetic Investigation
title Novel Carboranyl Derivatives of Nucleoside Mono- and Diphosphites and Phosphonates: A Synthetic Investigation
title_full Novel Carboranyl Derivatives of Nucleoside Mono- and Diphosphites and Phosphonates: A Synthetic Investigation
title_fullStr Novel Carboranyl Derivatives of Nucleoside Mono- and Diphosphites and Phosphonates: A Synthetic Investigation
title_full_unstemmed Novel Carboranyl Derivatives of Nucleoside Mono- and Diphosphites and Phosphonates: A Synthetic Investigation
title_short Novel Carboranyl Derivatives of Nucleoside Mono- and Diphosphites and Phosphonates: A Synthetic Investigation
title_sort novel carboranyl derivatives of nucleoside mono- and diphosphites and phosphonates: a synthetic investigation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267069/
https://www.ncbi.nlm.nih.gov/pubmed/18365067
http://dx.doi.org/10.1155/S1565363304000032
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