Structural Features of Antitumor Titanium Agents and Related Compounds

Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Parti...

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Detalles Bibliográficos
Autores principales: Caruso, Francesco, Rossi, Miriam, Opazo, Cristian, Pettinari, Claudio
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267096/
https://www.ncbi.nlm.nih.gov/pubmed/18365107
http://dx.doi.org/10.1155/BCA.2005.317
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author Caruso, Francesco
Rossi, Miriam
Opazo, Cristian
Pettinari, Claudio
author_facet Caruso, Francesco
Rossi, Miriam
Opazo, Cristian
Pettinari, Claudio
author_sort Caruso, Francesco
collection PubMed
description Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Particularly noteworthy features are that Ti-O bonds are short and Ti-O-Ti bond angles are large, demonstrating that in these compounds the O binding has high s-character approaching sp hybridization.
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spelling pubmed-22670962008-03-24 Structural Features of Antitumor Titanium Agents and Related Compounds Caruso, Francesco Rossi, Miriam Opazo, Cristian Pettinari, Claudio Bioinorg Chem Appl Research Article Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Particularly noteworthy features are that Ti-O bonds are short and Ti-O-Ti bond angles are large, demonstrating that in these compounds the O binding has high s-character approaching sp hybridization. Hindawi Publishing Corporation 2005 /pmc/articles/PMC2267096/ /pubmed/18365107 http://dx.doi.org/10.1155/BCA.2005.317 Text en Copyright © 2005 Francesco Caruso et al. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Caruso, Francesco
Rossi, Miriam
Opazo, Cristian
Pettinari, Claudio
Structural Features of Antitumor Titanium Agents and Related Compounds
title Structural Features of Antitumor Titanium Agents and Related Compounds
title_full Structural Features of Antitumor Titanium Agents and Related Compounds
title_fullStr Structural Features of Antitumor Titanium Agents and Related Compounds
title_full_unstemmed Structural Features of Antitumor Titanium Agents and Related Compounds
title_short Structural Features of Antitumor Titanium Agents and Related Compounds
title_sort structural features of antitumor titanium agents and related compounds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267096/
https://www.ncbi.nlm.nih.gov/pubmed/18365107
http://dx.doi.org/10.1155/BCA.2005.317
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AT pettinariclaudio structuralfeaturesofantitumortitaniumagentsandrelatedcompounds

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