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Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity

BACKGROUND: Iron regulatory protein 2 (IRP2), a post-transcriptional regulator of cellular iron metabolism, undergoes iron-dependent degradation via the ubiquitin-proteasome pathway. A stretch of 73 amino acids within the N-terminal domain 1 of the protein was reported to function as an iron sensor....

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Detalles Bibliográficos
Autores principales:	Wang, Jian, Chen, Guohua, Lee, Julie, Pantopoulos, Kostas
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267205/ https://www.ncbi.nlm.nih.gov/pubmed/18226225 http://dx.doi.org/10.1186/1471-2199-9-15

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