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The PIT1 gene polymorphisms were associated with chicken growth traits
BACKGROUND: With crucial roles on the differentiation of anterior pituitary and the regulation of the prolactin (PRL), growth hormone (GH) and thyroid-stimulating hormone-β (TSH-β) genes, the chicken PIT1 gene is regarded as a key candidate gene for production traits. In this study, five reported po...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267206/ https://www.ncbi.nlm.nih.gov/pubmed/18304318 http://dx.doi.org/10.1186/1471-2156-9-20 |
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author | Nie, Qinghua Fang, Meixia Xie, Liang Zhou, Min Liang, Zhangmin Luo, Ziping Wang, Guohuang Bi, Wensen Liang, Canjian Zhang, Wei Zhang, Xiquan |
author_facet | Nie, Qinghua Fang, Meixia Xie, Liang Zhou, Min Liang, Zhangmin Luo, Ziping Wang, Guohuang Bi, Wensen Liang, Canjian Zhang, Wei Zhang, Xiquan |
author_sort | Nie, Qinghua |
collection | PubMed |
description | BACKGROUND: With crucial roles on the differentiation of anterior pituitary and the regulation of the prolactin (PRL), growth hormone (GH) and thyroid-stimulating hormone-β (TSH-β) genes, the chicken PIT1 gene is regarded as a key candidate gene for production traits. In this study, five reported polymorphisms (MR1-MR5) of the PIT1 gene were genotyped in a full sib F(2 )resource population to evaluate their effects on growth, carcass and fatty traits in chickens. RESULTS: Marker-trait association analyses showed that, MR1 was significantly associated with shank diameters (SD) at 84 days (P < 0.05), hatch weight (HW) and shank length (SL) at 84 days (P < 0.01), MR2 was significantly associated with BW at 28, 42 days and average daily gain (ADG) at 0–4 weeks (P < 0.05), and MR3 was significantly associated with ADG at 4–8 weeks (P < 0.05). MR4 was associated with SL at 63, 77, 84 days and BW at 84 days (P < 0.05), as well as SD at 77 days (P < 0.01). Significant association was also found of MR5 with BW at 21, 35 days and SD at 63 days (P < 0.05), BW at 28 days and ADG at 0–4 weeks (P < 0.01). Both T allele of MR4 and C allele of MR5 were advantageous for chicken growth. The PIT1 haplotypes were significantly associated with HW (P = 0.0252), BW at 28 days (P = 0.0390) and SD at 56 days (P = 0.0400). No significant association of single SNP and haplotypes with chicken carcass and fatty traits was found (P > 0.05). CONCLUSION: Our study found that polymorphisms of PIT1 gene and their haplotypes were associated with chicken growth traits and not with carcass and fatty traits. |
format | Text |
id | pubmed-2267206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22672062008-03-13 The PIT1 gene polymorphisms were associated with chicken growth traits Nie, Qinghua Fang, Meixia Xie, Liang Zhou, Min Liang, Zhangmin Luo, Ziping Wang, Guohuang Bi, Wensen Liang, Canjian Zhang, Wei Zhang, Xiquan BMC Genet Research Article BACKGROUND: With crucial roles on the differentiation of anterior pituitary and the regulation of the prolactin (PRL), growth hormone (GH) and thyroid-stimulating hormone-β (TSH-β) genes, the chicken PIT1 gene is regarded as a key candidate gene for production traits. In this study, five reported polymorphisms (MR1-MR5) of the PIT1 gene were genotyped in a full sib F(2 )resource population to evaluate their effects on growth, carcass and fatty traits in chickens. RESULTS: Marker-trait association analyses showed that, MR1 was significantly associated with shank diameters (SD) at 84 days (P < 0.05), hatch weight (HW) and shank length (SL) at 84 days (P < 0.01), MR2 was significantly associated with BW at 28, 42 days and average daily gain (ADG) at 0–4 weeks (P < 0.05), and MR3 was significantly associated with ADG at 4–8 weeks (P < 0.05). MR4 was associated with SL at 63, 77, 84 days and BW at 84 days (P < 0.05), as well as SD at 77 days (P < 0.01). Significant association was also found of MR5 with BW at 21, 35 days and SD at 63 days (P < 0.05), BW at 28 days and ADG at 0–4 weeks (P < 0.01). Both T allele of MR4 and C allele of MR5 were advantageous for chicken growth. The PIT1 haplotypes were significantly associated with HW (P = 0.0252), BW at 28 days (P = 0.0390) and SD at 56 days (P = 0.0400). No significant association of single SNP and haplotypes with chicken carcass and fatty traits was found (P > 0.05). CONCLUSION: Our study found that polymorphisms of PIT1 gene and their haplotypes were associated with chicken growth traits and not with carcass and fatty traits. BioMed Central 2008-02-27 /pmc/articles/PMC2267206/ /pubmed/18304318 http://dx.doi.org/10.1186/1471-2156-9-20 Text en Copyright © 2008 Nie et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nie, Qinghua Fang, Meixia Xie, Liang Zhou, Min Liang, Zhangmin Luo, Ziping Wang, Guohuang Bi, Wensen Liang, Canjian Zhang, Wei Zhang, Xiquan The PIT1 gene polymorphisms were associated with chicken growth traits |
title | The PIT1 gene polymorphisms were associated with chicken growth traits |
title_full | The PIT1 gene polymorphisms were associated with chicken growth traits |
title_fullStr | The PIT1 gene polymorphisms were associated with chicken growth traits |
title_full_unstemmed | The PIT1 gene polymorphisms were associated with chicken growth traits |
title_short | The PIT1 gene polymorphisms were associated with chicken growth traits |
title_sort | pit1 gene polymorphisms were associated with chicken growth traits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267206/ https://www.ncbi.nlm.nih.gov/pubmed/18304318 http://dx.doi.org/10.1186/1471-2156-9-20 |
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