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The PIT1 gene polymorphisms were associated with chicken growth traits

BACKGROUND: With crucial roles on the differentiation of anterior pituitary and the regulation of the prolactin (PRL), growth hormone (GH) and thyroid-stimulating hormone-β (TSH-β) genes, the chicken PIT1 gene is regarded as a key candidate gene for production traits. In this study, five reported po...

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Autores principales: Nie, Qinghua, Fang, Meixia, Xie, Liang, Zhou, Min, Liang, Zhangmin, Luo, Ziping, Wang, Guohuang, Bi, Wensen, Liang, Canjian, Zhang, Wei, Zhang, Xiquan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267206/
https://www.ncbi.nlm.nih.gov/pubmed/18304318
http://dx.doi.org/10.1186/1471-2156-9-20
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author Nie, Qinghua
Fang, Meixia
Xie, Liang
Zhou, Min
Liang, Zhangmin
Luo, Ziping
Wang, Guohuang
Bi, Wensen
Liang, Canjian
Zhang, Wei
Zhang, Xiquan
author_facet Nie, Qinghua
Fang, Meixia
Xie, Liang
Zhou, Min
Liang, Zhangmin
Luo, Ziping
Wang, Guohuang
Bi, Wensen
Liang, Canjian
Zhang, Wei
Zhang, Xiquan
author_sort Nie, Qinghua
collection PubMed
description BACKGROUND: With crucial roles on the differentiation of anterior pituitary and the regulation of the prolactin (PRL), growth hormone (GH) and thyroid-stimulating hormone-β (TSH-β) genes, the chicken PIT1 gene is regarded as a key candidate gene for production traits. In this study, five reported polymorphisms (MR1-MR5) of the PIT1 gene were genotyped in a full sib F(2 )resource population to evaluate their effects on growth, carcass and fatty traits in chickens. RESULTS: Marker-trait association analyses showed that, MR1 was significantly associated with shank diameters (SD) at 84 days (P < 0.05), hatch weight (HW) and shank length (SL) at 84 days (P < 0.01), MR2 was significantly associated with BW at 28, 42 days and average daily gain (ADG) at 0–4 weeks (P < 0.05), and MR3 was significantly associated with ADG at 4–8 weeks (P < 0.05). MR4 was associated with SL at 63, 77, 84 days and BW at 84 days (P < 0.05), as well as SD at 77 days (P < 0.01). Significant association was also found of MR5 with BW at 21, 35 days and SD at 63 days (P < 0.05), BW at 28 days and ADG at 0–4 weeks (P < 0.01). Both T allele of MR4 and C allele of MR5 were advantageous for chicken growth. The PIT1 haplotypes were significantly associated with HW (P = 0.0252), BW at 28 days (P = 0.0390) and SD at 56 days (P = 0.0400). No significant association of single SNP and haplotypes with chicken carcass and fatty traits was found (P > 0.05). CONCLUSION: Our study found that polymorphisms of PIT1 gene and their haplotypes were associated with chicken growth traits and not with carcass and fatty traits.
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spelling pubmed-22672062008-03-13 The PIT1 gene polymorphisms were associated with chicken growth traits Nie, Qinghua Fang, Meixia Xie, Liang Zhou, Min Liang, Zhangmin Luo, Ziping Wang, Guohuang Bi, Wensen Liang, Canjian Zhang, Wei Zhang, Xiquan BMC Genet Research Article BACKGROUND: With crucial roles on the differentiation of anterior pituitary and the regulation of the prolactin (PRL), growth hormone (GH) and thyroid-stimulating hormone-β (TSH-β) genes, the chicken PIT1 gene is regarded as a key candidate gene for production traits. In this study, five reported polymorphisms (MR1-MR5) of the PIT1 gene were genotyped in a full sib F(2 )resource population to evaluate their effects on growth, carcass and fatty traits in chickens. RESULTS: Marker-trait association analyses showed that, MR1 was significantly associated with shank diameters (SD) at 84 days (P < 0.05), hatch weight (HW) and shank length (SL) at 84 days (P < 0.01), MR2 was significantly associated with BW at 28, 42 days and average daily gain (ADG) at 0–4 weeks (P < 0.05), and MR3 was significantly associated with ADG at 4–8 weeks (P < 0.05). MR4 was associated with SL at 63, 77, 84 days and BW at 84 days (P < 0.05), as well as SD at 77 days (P < 0.01). Significant association was also found of MR5 with BW at 21, 35 days and SD at 63 days (P < 0.05), BW at 28 days and ADG at 0–4 weeks (P < 0.01). Both T allele of MR4 and C allele of MR5 were advantageous for chicken growth. The PIT1 haplotypes were significantly associated with HW (P = 0.0252), BW at 28 days (P = 0.0390) and SD at 56 days (P = 0.0400). No significant association of single SNP and haplotypes with chicken carcass and fatty traits was found (P > 0.05). CONCLUSION: Our study found that polymorphisms of PIT1 gene and their haplotypes were associated with chicken growth traits and not with carcass and fatty traits. BioMed Central 2008-02-27 /pmc/articles/PMC2267206/ /pubmed/18304318 http://dx.doi.org/10.1186/1471-2156-9-20 Text en Copyright © 2008 Nie et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nie, Qinghua
Fang, Meixia
Xie, Liang
Zhou, Min
Liang, Zhangmin
Luo, Ziping
Wang, Guohuang
Bi, Wensen
Liang, Canjian
Zhang, Wei
Zhang, Xiquan
The PIT1 gene polymorphisms were associated with chicken growth traits
title The PIT1 gene polymorphisms were associated with chicken growth traits
title_full The PIT1 gene polymorphisms were associated with chicken growth traits
title_fullStr The PIT1 gene polymorphisms were associated with chicken growth traits
title_full_unstemmed The PIT1 gene polymorphisms were associated with chicken growth traits
title_short The PIT1 gene polymorphisms were associated with chicken growth traits
title_sort pit1 gene polymorphisms were associated with chicken growth traits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267206/
https://www.ncbi.nlm.nih.gov/pubmed/18304318
http://dx.doi.org/10.1186/1471-2156-9-20
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