Massive Autophosphorylation of the Ser/Thr-Rich Domain Controls Protein Kinase Activity of TRPM6 and TRPM7

TRPM6 and TRPM7 are bifunctional proteins expressing a TRP channel fused to an atypical α-kinase domain. While the gating properties of TRPM6 and TRPM7 channels have been studied in detail, little is known about the mechanisms regulating kinase activity. Recently, we found that TRPM7 associates with...

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Detalles Bibliográficos
Autores principales: Clark, Kristopher, Middelbeek, Jeroen, Morrice, Nick A., Figdor, Carl G., Lasonder, Edwin, van Leeuwen, Frank N.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267223/
https://www.ncbi.nlm.nih.gov/pubmed/18365021
http://dx.doi.org/10.1371/journal.pone.0001876

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