Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

BACKGROUND: MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mu...

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Detalles Bibliográficos
Autores principales: Heazlewood, Chad K, Cook, Matthew C, Eri, Rajaraman, Price, Gareth R, Tauro, Sharyn B, Taupin, Douglas, Thornton, David J, Png, Chin Wen, Crockford, Tanya L, Cornall, Richard J, Adams, Rachel, Kato, Masato, Nelms, Keats A, Hong, Nancy A, Florin, Timothy H. J, Goodnow, Christopher C, McGuckin, Michael A
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270292/
https://www.ncbi.nlm.nih.gov/pubmed/18318598
http://dx.doi.org/10.1371/journal.pmed.0050054

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