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Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

In response to misaligned sister chromatids during mitosis, the spindle checkpoint protein Mad2 inhibits the anaphase-promoting complex or cyclosome (APC/C) through binding to its mitotic activator Cdc20, thus delaying anaphase onset. Mad1, an upstream regulator of Mad2, forms a tight core complex w...

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Detalles Bibliográficos
Autores principales:	Yang, Maojun, Li, Bing, Liu, Chyong-Jy, Tomchick, Diana R, Machius, Mischa, Rizo, Josep, Yu, Hongtao, Luo, Xuelian
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270309/ https://www.ncbi.nlm.nih.gov/pubmed/18318601 http://dx.doi.org/10.1371/journal.pbio.0060050

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