Cargando…

Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance

In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) α-synuclein (αS) pathology is seen that displays a predictable topographic distribution. There are two staging/categorization systems, i.e. Braak’s and McKeith’s, currently in use for the assessment of αS pathology. The aim of these dia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parkkinen, Laura, Pirttilä, Tuula, Alafuzoff, Irina
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2008
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270355/ https://www.ncbi.nlm.nih.gov/pubmed/18297293 http://dx.doi.org/10.1007/s00401-008-0346-6

Ejemplares similares

Gut Feelings About α‐Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?
por: Ruffmann, Claudio, et al.
Publicado: (2016)

SUMOylation in α-Synuclein Homeostasis and Pathology
por: Savyon, Mor, et al.
Publicado: (2020)

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
por: Sacino, Amanda N, et al.
Publicado: (2013)

Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells
por: Sutinen, Elina M., et al.
Publicado: (2014)

Propagation of pathological α-synuclein in marmoset brain
por: Shimozawa, Aki, et al.
Publicado: (2017)

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
por: Braak, Heiko, et al.
Publicado: (2006)

Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders
por: Altay, Melek Firat, et al.
Publicado: (2022)

α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications
por: Li, Amanda, et al.
Publicado: (2022)

Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease
por: Reyes, Juan F., et al.
Publicado: (2021)

Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer
por: Zuo, Li-Jun, et al.
Publicado: (2016)

Prion-like spreading of pathological α-synuclein in brain
por: Masuda-Suzukake, Masami, et al.
Publicado: (2013)

Determinants of seeding and spreading of α-synuclein pathology in the brain
por: Henrich, Martin T., et al.
Publicado: (2020)

Initiation and progression of α-synuclein pathology in Parkinson’s disease
por: Tofaris, George K.
Publicado: (2022)

α-Synuclein serine129 phosphorylation – the physiology of pathology
por: Ramalingam, Nagendran, et al.
Publicado: (2023)

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?
por: Tripathi, Arati, et al.
Publicado: (2021)

Cellular Milieu Imparts Distinct Pathological α-Synuclein Strains in α-Synucleinopathies
por: Peng, Chao, et al.
Publicado: (2018)

Examining the mechanisms that link β-amyloid and α-synuclein pathologies
por: Marsh, Samuel E, et al.
Publicado: (2012)

Effect of L-DOPA/Benserazide on Propagation of Pathological α-Synuclein
por: Shimozawa, Aki, et al.
Publicado: (2019)

Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin
por: Kam, Tae-In, et al.
Publicado: (2022)

Association of Glial Activation and α-Synuclein Pathology in Parkinson’s Disease
por: Wang, Rui, et al.
Publicado: (2022)

Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage
por: Majbour, Nour, et al.
Publicado: (2022)

Clinical Neuropathology image 5-2014: α-synuclein pathology in the ependyma in Parkinson’s disease
por: Kovacs, Gabor
Publicado: (2014)

Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance
por: Lemos, Miguel, et al.
Publicado: (2020)

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
por: Choi, Minee L., et al.
Publicado: (2022)

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease
por: Twohig, Daniel, et al.
Publicado: (2018)

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils
por: Dhillon, Jess-Karan S., et al.
Publicado: (2019)

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD
por: Hoban, Deirdre B., et al.
Publicado: (2020)

α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
por: Hart de Ruyter, Frederique J., et al.
Publicado: (2023)

α-Synuclein–Confocal Nanoscanning (ASYN-CONA), a Bead-Based Assay for Detecting Early-Stage α-Synuclein Aggregation
por: Pérez-Pi, Irene, et al.
Publicado: (2019)

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA
por: Bétemps, Dominique, et al.
Publicado: (2014)

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis
por: van den Berge, Simone A., et al.
Publicado: (2012)

Analysis of α-Synuclein Pathology in PINK1 Knockout Rat Brains
por: Creed, Rose B., et al.
Publicado: (2019)

Lipids at the Crossroad of α-Synuclein Function and Dysfunction: Biological and Pathological Implications
por: Alza, Natalia P., et al.
Publicado: (2019)

Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
por: Raunio, Anna, et al.
Publicado: (2017)

Structures of α-synuclein filaments from human brains with Lewy pathology
por: Yang, Yang, et al.
Publicado: (2022)

α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
por: Suzuki, Genjiro, et al.
Publicado: (2020)

Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson’s Disease Pathology
por: Yuan, Xin, et al.
Publicado: (2022)

Prion-like α-synuclein pathology in the brain of infants with Krabbe disease
por: Hatton, Christopher, et al.
Publicado: (2022)

MhcII Regulates Transmission of α-Synuclein-Seeded Pathology in Mice
por: Gonzalez De La Cruz, Elsa, et al.
Publicado: (2022)

Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson’s disease
por: Yang, Yunseon, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vnu0oe32r5hhiks9mf1p7gj2kr