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Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

AIMS/HYPOTHESIS: Insulin secretion in pancreatic islets is dependent upon mitochondrial function and production of ATP. The transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1α; gene PPARGC1A) is a master regulator of mitochondrial genes an...

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Detalles Bibliográficos
Autores principales:	Ling, C., Del Guerra, S., Lupi, R., Rönn, T., Granhall, C., Luthman, H., Masiello, P., Marchetti, P., Groop, L., Del Prato, S.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270364/ https://www.ncbi.nlm.nih.gov/pubmed/18270681 http://dx.doi.org/10.1007/s00125-007-0916-5

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